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Table 1 Genes regulated by BCR-ABL.

From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

A. Microarray Analysis
Genes Regulated by BCR-ABL
  Fold-Change Gene Name
Induced Genes 13.00 Complement component 3 (C3)
  12.12 Murine retrovirus integration site 1 (Mrvi1)*
  11.31 CD55 antigen (CD55)*
  4.29 N-myc downstream regulated gene 1 (Ndrg1)*
  3.48 Downstream of Tyrosine kinase 2 (Dok2)
  2.64 CCAAT enhancer binding protein, beta (Cebpb)
  2.46 A disintegrin and metalloprotease domain 8 (Adam8)
  2.46 Arrestin, beta 2 (Arrb2)
  2.40 Selectin, lymphocyte (Sell)
  2.30 Talin (Tln)
  2.30 Enolase 3, beta muscle (Eno3)
Suppressed Genes 3.03 Interleukin-15 (Il15)
  3.03 Neuronal pentraxin receptor (Nptxr)
  3.03 Ciliary neurotrophic factor (Cntf)
  2.64 Vimentin (Vmn)
  2.46 Suppression of tumorigenicity 7 (St7)
  2.30 Nuclear factor IX (Nfix)
  2.30 Growth arrest specific 5 (Gas5)
  2.14 Ribosomal protein S20 (Rps20)
B. Validation by Quantitative PCR
Gene Name Mean Fold-Change p -Value
Cd55 4.87 ± 1.31 0.02
Dok2 4.57 ± 1.82 0.07
Mrvi1 11.08 ± 0.76 0.0001
Ndrg1 4.92 ± 0.50 0.01
  1. (A) Selected genes induced or suppressed by BCR-ABL by two-fold or more after 1 week of activation. Genes chosen for validation by Q-PCR are denoted by asterisks. (B) Q-PCR was performed in triplicate using RNA samples extracted from 2-4 distinct cell populations Mean fold-induction at 1 week compared to the expression at 0 h and standard error mean (SEM) are shown for each gene. A student t-test was performed to obtain P-values for the difference between the mean gene expression level at 0 h and 1 week. "I" and "S" denote "induced" and "suppressed", respectively
  2. Although not selected for the validation study, Talin was previously reported to be induced in a BCR-ABL expressing cell line [31, 32].