From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events
A. Microarray Analysis | ||
---|---|---|
Genes Regulated by BCR-ABL | ||
Fold-Change | Gene Name | |
Induced Genes | 13.00 | Complement component 3 (C3) |
12.12 | Murine retrovirus integration site 1 (Mrvi1)* | |
11.31 | CD55 antigen (CD55)* | |
4.29 | N-myc downstream regulated gene 1 (Ndrg1)* | |
3.48 | Downstream of Tyrosine kinase 2 (Dok2) | |
2.64 | CCAAT enhancer binding protein, beta (Cebpb) | |
2.46 | A disintegrin and metalloprotease domain 8 (Adam8) | |
2.46 | Arrestin, beta 2 (Arrb2) | |
2.40 | Selectin, lymphocyte (Sell) | |
2.30 | Talin (Tln) | |
2.30 | Enolase 3, beta muscle (Eno3) | |
Suppressed Genes | 3.03 | Interleukin-15 (Il15) |
3.03 | Neuronal pentraxin receptor (Nptxr) | |
3.03 | Ciliary neurotrophic factor (Cntf) | |
2.64 | Vimentin (Vmn) | |
2.46 | Suppression of tumorigenicity 7 (St7) | |
2.30 | Nuclear factor IX (Nfix) | |
2.30 | Growth arrest specific 5 (Gas5) | |
2.14 | Ribosomal protein S20 (Rps20) | |
B. Validation by Quantitative PCR | ||
Gene Name | Mean Fold-Change | p -Value |
Cd55 | 4.87 ± 1.31 | 0.02 |
Dok2 | 4.57 ± 1.82 | 0.07 |
Mrvi1 | 11.08 ± 0.76 | 0.0001 |
Ndrg1 | 4.92 ± 0.50 | 0.01 |