Table 2 The percentage of DNA methylation in CpG rich regions in primary cancerous and histopathologically unchanged tissue samples from patients with CRC.
n = 52 | Primary cancerous tissues | Histopathologically unchanged tissues | pa | |||
|---|---|---|---|---|---|---|
Median (range) | Mean (± SD) | Median (range) | Mean (± SD) | |||
Age | ||||||
<60 | 10 | 21.05 (12.89-25.79) | 20.66 ± 4.205 | 19.47 (13.16-28.42) | 19.32 ± 4.875 | 0.5181 |
>60 | 42 | 20.00 (4.211-33.16) | 20.91 ± 7.074 | 18.95 (2.105-36.21) | 18.42 ± 6.779 | 0.1076 |
Gender | ||||||
Female | 20 | 24.21 (16.84-33.16) | 24.42 ± 4.516 | 23.68 (13.68-28.42) | 21.75 ± 4.499 | 0.1155 |
Male | 32 | 18.95 (4.211-32.11) | 19.51 ± 7.255 | 17.37 (2.105-36.21) | 18.43 ± 7.206 | 0.5594 |
CRC localization | ||||||
Proximal colon (cecum to transverse) | 20 | 24.21 ( 13.68-33.16) | 23.54 ± 5.793 | 17.63 ( 2.105435.79) | 17.61 ± 6.050 | 0.0030 |
Distal colon (splenic flexture to sigmoid) | 12 | 19.47 (4.211-28.95) | 19.69 ± 7.159 | 18.95 (10.53-25.26) | 18.85 ± 4.747 | 0.7498 |
Rectum | 20 | 19.47 (6.316-28.42) | 19.36 ± 6.292 | 19.47 (4.737-36.21) | 19.30 ± 7.851 | 0.9810 |
Histologic grade | ||||||
G1 | 4 | 21.32 (13.68-28.42) | 21.18 ± 8.067 | 17.89 (2.105-27.89) | 16.45 ± 10.97 | 0.5126 |
G2 | 35 | 20.00 (10.53-30.53) | 21.17 ± 5.293 | 19.47 (4.737-28.42) | 18.93 ± 5.884 | 0.0996 |
G3 | 13 | 21.84 (4.211-33.16) | 20.21 ± 9.397 | 15.53 (12.63-36.21) | 18.11 ± 6.727 | 0.4021 |