The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Table 3 Meta-analysis of the APE1 1349 T > G polymorphism and cancer risk

Variables	n *	GG vs. TT		TG vs. TT		GG/TG vs. TT		GG vs. TT/TG
		OR (95% CI) ^†	P ^‡	OR (95% CI) ^†	P ^‡	OR (95% CI) ^†	P ^‡	OR (95% CI) ^†	P ^‡
Total	35	1.05 (0.95-1.16)	0.001	1.04 (0.96-1.12)	0.004	1.04 (0.97-1.13)	0.000	1.03 (0.96-1.11)	0.022
Ethnicities
Asian	10	1.05 (0.93-1.20)	0.051	0.97 (0.88-1.07)	0.657	0.99 (0.90-1.08)	0.427	1.08 (0.92-1.28)	0.035
European	23	1.05 (0.92-1.19)	0.001	1.09 (0.99-1.20)	0.003	1.09 (0.98-1.21)	0.000	1.00 (0.94-1.07)	0.062
Source of controls
Population-based	15	1.01 (0.92-1.11)	0.130	1.07 (0.95-1.21)	0.010	1.06 (094-1.20)	0.004	0.98 (0.90-1.07)	0.335
Hospital-based	20	1.07 (0.92-1.24)	0.000	1.02 (0.93-1.11)	0.048	1.03 (0.93-1.15)	0.002	1.06 (0.95-1.20)	0.014
Cancer types
Lung cancer	9	1.08 (0.85-1.38)	0.017	0.99 (0.84-1.17)	0.059	1.03 (0.85-1.25)	0.007	1.04 (0.92-1.19)	0.086
Bladder cancer	7	0.96 (0.83-1.09)	0.312	1.01 (0.91-1.12)	0.376	0.99 (0.90-1.10)	0.453	0.95 (0.85-1.07)	0.360
Colorectal cancer	4	0.93 (0.55-1.57)	0.001	1.05 (0.78-1.41)	0.025	1.01 (0.72-1.43)	0.003	0.93 (0.63-1.39)	0.003
Breast cancer	4	1.20 (0.82-1.76)	0.042	1.19 (0.76-1.86)	0.000	1.23 (0.79-1.92)	0.000	1.06 (0.92-1.23)	0.345
Head and neck cancer	2	1.03 (0.80-1.32)	0.306	1.00 (0.81-1.23)	0.242	1.01 (0.83-1.23)	0.202	1.03 (0.83-1.27)	0.621
Others	9	1.07 (0.94-1.23)	0.156	1.05 (0.94-1.16)	0.754	1.05 (0.96-1.16)	0.609	1.05 (0.93-1.18)	0.111

* Number of comparisons
^† Random-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used
^‡ P value of Q-test for heterogeneity test

ISSN: 1471-2407