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Table 3 Meta-analysis of the APE1 1349 T > G polymorphism and cancer risk

From: The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Variables n * GG vs. TT TG vs. TT GG/TG vs. TT GG vs. TT/TG
   OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total 35 1.05 (0.95-1.16) 0.001 1.04 (0.96-1.12) 0.004 1.04 (0.97-1.13) 0.000 1.03 (0.96-1.11) 0.022
Ethnicities
Asian 10 1.05 (0.93-1.20) 0.051 0.97 (0.88-1.07) 0.657 0.99 (0.90-1.08) 0.427 1.08 (0.92-1.28) 0.035
European 23 1.05 (0.92-1.19) 0.001 1.09 (0.99-1.20) 0.003 1.09 (0.98-1.21) 0.000 1.00 (0.94-1.07) 0.062
Source of controls
Population-based 15 1.01 (0.92-1.11) 0.130 1.07 (0.95-1.21) 0.010 1.06 (094-1.20) 0.004 0.98 (0.90-1.07) 0.335
Hospital-based 20 1.07 (0.92-1.24) 0.000 1.02 (0.93-1.11) 0.048 1.03 (0.93-1.15) 0.002 1.06 (0.95-1.20) 0.014
Cancer types
Lung cancer 9 1.08 (0.85-1.38) 0.017 0.99 (0.84-1.17) 0.059 1.03 (0.85-1.25) 0.007 1.04 (0.92-1.19) 0.086
Bladder cancer 7 0.96 (0.83-1.09) 0.312 1.01 (0.91-1.12) 0.376 0.99 (0.90-1.10) 0.453 0.95 (0.85-1.07) 0.360
Colorectal cancer 4 0.93 (0.55-1.57) 0.001 1.05 (0.78-1.41) 0.025 1.01 (0.72-1.43) 0.003 0.93 (0.63-1.39) 0.003
Breast cancer 4 1.20 (0.82-1.76) 0.042 1.19 (0.76-1.86) 0.000 1.23 (0.79-1.92) 0.000 1.06 (0.92-1.23) 0.345
Head and neck cancer 2 1.03 (0.80-1.32) 0.306 1.00 (0.81-1.23) 0.242 1.01 (0.83-1.23) 0.202 1.03 (0.83-1.27) 0.621
Others 9 1.07 (0.94-1.23) 0.156 1.05 (0.94-1.16) 0.754 1.05 (0.96-1.16) 0.609 1.05 (0.93-1.18) 0.111
  1. * Number of comparisons
  2. Random-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used
  3. P value of Q-test for heterogeneity test