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Table 2 Meta-analysis of the APE1 −656 T > G polymorphism and cancer risk

From: The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Variables

n *

GG vs. TT

TG vs. TT

GG/TG vs. TT

GG vs. TT/TG

  

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Total

8

0.81 (0.67-0.97)

0.015

0.92 (0.83-1.01)

0.340

0.89 (0.81-0.97)

0.084

0.90 (0.82-0.98)

0.059

Ethnicities

Asian

6

0.75 (0.65-0.86)

0.057

0.89 (0.80-0.99)

0.255

0.85 (0.77-0.94)

0.093

0.81(0.71-0.91)

0.252

European

2

1.04 (0.85-1.28)

0.703

1.01 (0.83-1.24)

0.692

1.03 (0.85-1.24)

0.680

1.03 (0.90-1.18)

0.891

Cancer types

Lung cancer

3

0.65 (0.54-0.79)

0.857

0.83 (0.72-0.97)

0.469

0.78 (0.68-0.89)

0.602

0.72 (0.61-0.86)

0.799

Bladder cancer

2

0.88 (0.70-1.12)

0.045

0.89 (0.72-1.11)

0.583

0.88 (0.71-1.08)

0.097

0.97 (0.82-1.14)

0.086

Others

3

1.00 (0.83-1.19)

0.276

1.03 (0.88-1.19)

0.340

1.02 (0.88-1.15)

0.397

0.98 (0.85-1.13)

0.437

  1. * Number of comparisons
  2. Random-effects model was used when P value for heterogeneity test < 0.05; otherwise, fix-effects model was used
  3. P value of Q-test for heterogeneity test