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Table 2 Meta-analysis of the APE1 −656 T > G polymorphism and cancer risk

From: The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Variables n * GG vs. TT TG vs. TT GG/TG vs. TT GG vs. TT/TG
   OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Total 8 0.81 (0.67-0.97) 0.015 0.92 (0.83-1.01) 0.340 0.89 (0.81-0.97) 0.084 0.90 (0.82-0.98) 0.059
Ethnicities
Asian 6 0.75 (0.65-0.86) 0.057 0.89 (0.80-0.99) 0.255 0.85 (0.77-0.94) 0.093 0.81(0.71-0.91) 0.252
European 2 1.04 (0.85-1.28) 0.703 1.01 (0.83-1.24) 0.692 1.03 (0.85-1.24) 0.680 1.03 (0.90-1.18) 0.891
Cancer types
Lung cancer 3 0.65 (0.54-0.79) 0.857 0.83 (0.72-0.97) 0.469 0.78 (0.68-0.89) 0.602 0.72 (0.61-0.86) 0.799
Bladder cancer 2 0.88 (0.70-1.12) 0.045 0.89 (0.72-1.11) 0.583 0.88 (0.71-1.08) 0.097 0.97 (0.82-1.14) 0.086
Others 3 1.00 (0.83-1.19) 0.276 1.03 (0.88-1.19) 0.340 1.02 (0.88-1.15) 0.397 0.98 (0.85-1.13) 0.437
  1. * Number of comparisons
  2. Random-effects model was used when P value for heterogeneity test < 0.05; otherwise, fix-effects model was used
  3. P value of Q-test for heterogeneity test