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Table 3 Cumulative 1- and 5 year survival and crude and adjusted hazard ratios of entire cohort

From: The influence of cardiovascular morbidity on the prognosis in prostate cancer. Experience from a 12-year nationwide Danish population-based cohort study

Variables

No. of patients, n (%)

1-year cumulative survival

5-year cumulative survival

HR (95% CI)

    

Crude

Adjusted

Overall

30,721

84.4%

41.7%

  

No IHD or stroke

25,114 (82)

85.4%

43.5%

1.0 (reference)

1.0 (reference)

IHD

4,276 (14)

80.5%

36.1%

1.25 (1.20-1.31)

1.05 (1.00-1.10)

Stroke

1,331 (4)

77.6%

26.5%

1.57 (1.46-1.69)

1.20 (1.12-1.30)

Stratified by age at prostate cancer diagnosis

     

< 60 year

     

No IHD or stroke

2,504

93.1%

62.3%

1.0 (reference)

1.0 (reference)

IHD

173

95.2%

50.1%

1.19 (0.90-1.57)

0.97 (0.73-1.29)

Stroke

53

90.6%

55.7%

1.28 (0.82-1.99)

1.18 (0.74-1.88)

60-69 year

     

No IHD or stroke

8,202

92.3%

59.4%

1.0 (reference)

1.0 (reference)

IHD

1,082

91.8%

56.3%

1.08 (0.96-1.22)

0.94 (0.84-1.06)

Stroke

284

89.3%

44.8%

1.51 (1.23-1.85)

1.19 (0.97-1.46)

≥ 70 year

     

No IHD or stroke

14,408

80.3%

33.2%

1.0 (reference)

1.0 (reference)

IHD

3,021

75.7%

28.8%

1.16 (1.10-1.23)

1.06 (1.00-1.12)

Stroke

994

73.6%

20.7%

1.38 (1.27-1.50)

1.20 (1.10-1.30)

  1. Cumulative 1- and 5 year survival and crude and adjusted hazard ratios (HRs) of all cause mortality in 30,721 prostate cancer patients by preexisting ischemic heart disease or stroke status. Overall and stratified by age group.
  2. Adjusted for age, stage, calendar period, comorbidity (except prostate cancer, IHD, and stroke) IHD = ischemic heart disease