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Table 1 Clinico-pathological variables and correlations with SOX2 and β-catenin protein expression in the matched case-control collection of 114 CC patients. OR = odds ratio, CI = 95% confidence interval, Percent-values are given in parentheses.

From: SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

Characteristic

Total (%)

SOX-2

OR (CI)

p

β-catenin (cytoplasmic)

OR (CI)

p

β-catenin (nuclear)

OR (CI)

p

  

high

low

  

high

low

  

high

low

  

All patients

114 (100)

24 (21.1)

90 (78.9)

  

104 (91.2)

10 (8.8)

  

38 (33.3)

76 (66.7)

  

Age (median. 66.5) years

   ≤ 66

57 (50)

11 (9.6)

46 (40.4)

1.2

0.646

56 (49.1)

1 (0.9)

0.1

0.008

22 (19.3)

35 (30.7)

0.6

0.23

   ≥67

57 (50)

13 (11.4)

44 (38.6)

(0.5-3.0)

 

48 (42.1)

9 (7.9)

(0.01-0.8)

 

16 (14.0)

41 (36.0)

(0.3-1.4)

 

Gender

   Male

58 (50.9)

15 (13.2)

43 (37.7)

1.8

0.20

54 (47.4)

4 (3.5)

1.6

0.471

22 (19.3)

36 (31.6)

1.5

0.29

   Female

56 (49.1)

9 (7.9)

47 (41.2)

(0.7-4.6)

 

50 (43.9)

6 (5.3)

(0.4-6.1)

 

16 (14.0)

40 (35.1)

(0.7-3.4)

 

Tumor size (UICC)

   T1

2 (1.8)

0 (0)

2 (1.8)

-

0.280

2 (1.8)

0 (0)

-

0.662

1 (0.9)

1 (0.9)

-

0.607

   T2

10 (8.8)

0 (0)

10 (8.8)

  

10 (8.8)

0 (0)

  

2 (1.8)

8 (7.0)

  

   T3

86 (75.4)

21 (18.4)

65 (57.0)

  

77 (67.5)

9 (7.9)

  

31 (27.2)

55 (48.2)

  

   T4

16 (14)

3 (2.6)

13 (11.4)

  

15 (13.2)

1 (0.9)

  

4 (3.5)

12 (10.5)

  

Nodal status

   N0

52 (45.6)

5 (4.4)

47 (41.2)

4.2

0.006

49 (43.0)

3 (2.6)

0.5

0.299

15 (13.2)

37 (32.5)

1.5

0.35

   N+

62 (54.4)

19 (16.7)

43 (37.7)

(1.4 - 12.1)

 

55 (48.2)

7 (6.1)

(0.1-2.0)

 

23 (20.2)

39 (34.2)

(0.7-3.2)

 

Metastasis (liver)

   M0

57 (50)

7 (6.1)

50 (43.9)

3.0

0.022

52 (45.6)

5 (4.4)

1.0

1.0

11 (9.6)

46 (40.4)

3.8

0.001

   M1

57 (50)

17 (14.9)

40 (35.1)

(1.1-3.0)

 

52 (45.6)

5 (4.4)

(0.3-3.7)

 

27 (23.7)

30 (26.3)

(1.6-8.7)

 

Tumor grade (WHO)

   G2

44 (38.6)

7 (6.1)

37 (32.5)

-

0.043

43 (37.7)

1 (0.9)

-

0.265

16 (14.0)

28 (24.6)

-

0.567

   G3

66 (57.9)

15 (13.2)

51 (44.7)

  

58 (50.9)

8 (7.0)

  

21 (18.4)

45 (39.5)

  

   G4

4 (3.5)

2 (1.8)

2 (1.8)

  

3 (2.6)

1 (0.9)

  

1 (0.9)

3 (2.6)