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Table 1 Clinico-pathological variables and correlations with SOX2 and β-catenin protein expression in the matched case-control collection of 114 CC patients. OR = odds ratio, CI = 95% confidence interval, Percent-values are given in parentheses.

From: SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

Characteristic Total (%) SOX-2 OR (CI) p β-catenin (cytoplasmic) OR (CI) p β-catenin (nuclear) OR (CI) p
   high low    high low    high low   
All patients 114 (100) 24 (21.1) 90 (78.9)    104 (91.2) 10 (8.8)    38 (33.3) 76 (66.7)   
Age (median. 66.5) years
   ≤ 66 57 (50) 11 (9.6) 46 (40.4) 1.2 0.646 56 (49.1) 1 (0.9) 0.1 0.008 22 (19.3) 35 (30.7) 0.6 0.23
   ≥67 57 (50) 13 (11.4) 44 (38.6) (0.5-3.0)   48 (42.1) 9 (7.9) (0.01-0.8)   16 (14.0) 41 (36.0) (0.3-1.4)  
Gender
   Male 58 (50.9) 15 (13.2) 43 (37.7) 1.8 0.20 54 (47.4) 4 (3.5) 1.6 0.471 22 (19.3) 36 (31.6) 1.5 0.29
   Female 56 (49.1) 9 (7.9) 47 (41.2) (0.7-4.6)   50 (43.9) 6 (5.3) (0.4-6.1)   16 (14.0) 40 (35.1) (0.7-3.4)  
Tumor size (UICC)
   T1 2 (1.8) 0 (0) 2 (1.8) - 0.280 2 (1.8) 0 (0) - 0.662 1 (0.9) 1 (0.9) - 0.607
   T2 10 (8.8) 0 (0) 10 (8.8)    10 (8.8) 0 (0)    2 (1.8) 8 (7.0)   
   T3 86 (75.4) 21 (18.4) 65 (57.0)    77 (67.5) 9 (7.9)    31 (27.2) 55 (48.2)   
   T4 16 (14) 3 (2.6) 13 (11.4)    15 (13.2) 1 (0.9)    4 (3.5) 12 (10.5)   
Nodal status
   N0 52 (45.6) 5 (4.4) 47 (41.2) 4.2 0.006 49 (43.0) 3 (2.6) 0.5 0.299 15 (13.2) 37 (32.5) 1.5 0.35
   N+ 62 (54.4) 19 (16.7) 43 (37.7) (1.4 - 12.1)   55 (48.2) 7 (6.1) (0.1-2.0)   23 (20.2) 39 (34.2) (0.7-3.2)  
Metastasis (liver)
   M0 57 (50) 7 (6.1) 50 (43.9) 3.0 0.022 52 (45.6) 5 (4.4) 1.0 1.0 11 (9.6) 46 (40.4) 3.8 0.001
   M1 57 (50) 17 (14.9) 40 (35.1) (1.1-3.0)   52 (45.6) 5 (4.4) (0.3-3.7)   27 (23.7) 30 (26.3) (1.6-8.7)  
Tumor grade (WHO)
   G2 44 (38.6) 7 (6.1) 37 (32.5) - 0.043 43 (37.7) 1 (0.9) - 0.265 16 (14.0) 28 (24.6) - 0.567
   G3 66 (57.9) 15 (13.2) 51 (44.7)    58 (50.9) 8 (7.0)    21 (18.4) 45 (39.5)   
   G4 4 (3.5) 2 (1.8) 2 (1.8)    3 (2.6) 1 (0.9)    1 (0.9) 3 (2.6)