Figure 2
From: Regulation of hTERT by BCR-ABL at multiple levels in K562 cells
Gleevec reduces hTERT mRNA level in K562 cells. (a) 1 μM Gleevec treatment for 16 h inhibits hTERT mRNA level in K562 but not in HL60 and Jurkat cells. Upper Panel: RT-PCR image; Lower Panel: Quantitation of the RT-PCR image. (b) hTERT mRNA level in K562 cells was gradually reduced with increased incubation time upon 1 μM Gleevec treatment. Upper Panel: RT-PCR image; Lower Panel: Quantitation of the RT-PCR image. (c) Endogenous proteins expression level of K562 cells under 1 μM Gleevec treatment for 2, 8 and 16 h