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Table 2 EGFR gene copy analysis by three-dimensional FISH

From: Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

No. of Patients (%), (n = 36)

Mean copy number

< 2.5

≥ 2.5- < 4.0

≥ 4.0- < 6.0

≥ 6.0

 

(normal)

(low level)

(high level)

(amplification)

EGFR

8 (22%)

20 (56%)

7 (19%)

1 (3%)

CEP7

11 (31%)

22 (61%)

2 (6%)

1 (3%)

Ratio

< 1.1

≥ 1.1-1.5

  

EGFR/CEP7

22 (61%)

14 (39%)

  
  1. Abbreviation: FISH fluorescence in situ hybridisation