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Table 2 EGFR gene copy analysis by three-dimensional FISH

From: Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

No. of Patients (%), (n = 36)
Mean copy number < 2.5 ≥ 2.5- < 4.0 ≥ 4.0- < 6.0 ≥ 6.0
  (normal) (low level) (high level) (amplification)
EGFR 8 (22%) 20 (56%) 7 (19%) 1 (3%)
CEP7 11 (31%) 22 (61%) 2 (6%) 1 (3%)
Ratio < 1.1 ≥ 1.1-1.5   
EGFR/CEP7 22 (61%) 14 (39%)   
  1. Abbreviation: FISH fluorescence in situ hybridisation