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Table 1 Deregulated WNT, TGF-β and BMP signaling in fusion-positive tumors:

From: TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

 

Own Data

Taylor et al. [20]

GeneSymbol

FC

p value

FC

p value

ACVR1

1.31

0.004

1.15

0.005

ACVR2B

1.33

< 0.001

1.11

0.007

BMP7

1.26

< 0.001

1.11

0.010

BMPR2

1.50

0.002

1.14

0.028

FZD3

1.72

< 0.001

1.28

0.011

FZD5

1.67

< 0.001

1.32

< 0.001

FZD7

1.29

0.005

1.12

0.442

FZD8

1.13

< 0.001

1.14

< 0.001

LRP1

1.89

< 0.001

1.35

< 0.001

LRP6

1.46

< 0.001

1.14

0.011

MAP3K7

1.42

< 0.001

1.17

0.005

PRKCH

1.25

0.002

1.09

0.074

PRKD1

1.86

< 0.001

1.47

< 0.001

SMAD2

1.45

0.005

1.18

0.006

SMAD5

1.50

< 0.001

1.28

< 0.001

SMAD9

1.29

0.002

1.20

< 0.001

TCF7L2

1.33

< 0.001

1.09

0.250

TGFBR3

1.44

< 0.001

1.11

0.231

  1. Deregulated genes from the top canonical pathway ("Factors promoting cardiogenesis") according to the overrepresentation analysis using Ingenuity Pathway Analysis software
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BMC Cancer

ISSN: 1471-2407

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