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Table 1 Deregulated WNT, TGF-β and BMP signaling in fusion-positive tumors:

From: TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

  Own Data Taylor et al. [20]
GeneSymbol FC p value FC p value
ACVR1 1.31 0.004 1.15 0.005
ACVR2B 1.33 < 0.001 1.11 0.007
BMP7 1.26 < 0.001 1.11 0.010
BMPR2 1.50 0.002 1.14 0.028
FZD3 1.72 < 0.001 1.28 0.011
FZD5 1.67 < 0.001 1.32 < 0.001
FZD7 1.29 0.005 1.12 0.442
FZD8 1.13 < 0.001 1.14 < 0.001
LRP1 1.89 < 0.001 1.35 < 0.001
LRP6 1.46 < 0.001 1.14 0.011
MAP3K7 1.42 < 0.001 1.17 0.005
PRKCH 1.25 0.002 1.09 0.074
PRKD1 1.86 < 0.001 1.47 < 0.001
SMAD2 1.45 0.005 1.18 0.006
SMAD5 1.50 < 0.001 1.28 < 0.001
SMAD9 1.29 0.002 1.20 < 0.001
TCF7L2 1.33 < 0.001 1.09 0.250
TGFBR3 1.44 < 0.001 1.11 0.231
  1. Deregulated genes from the top canonical pathway ("Factors promoting cardiogenesis") according to the overrepresentation analysis using Ingenuity Pathway Analysis software