Figure 2
From: Current views on the role of Notch signaling and the pathogenesis of human leukemia
The Notch signaling pathway. The initiation of the Notch signaling pathway begins when the Notch ligand binds to the Notch receptor. This action triggers two proteolytic cleavages by ADAM-type protease (S2) and γ-secretase (S3), respectively. Following cleavages, the activated form of Notch is released (NICD) and is translocated to the nucleus, where NICD forms complexes with specific DNA-binding proteins (CBF1/Suppressor of Hairless/LAG-1 and Mastermind/SEL-8). Afterward the transcriptional process of target genes is initiated. MAML1: Mastermind-like 1 protein; CBF1: DNA-binding transcription factor.