From: Adaptation to statins restricts human tumour growth in Nude mice
Lipids synthesis | HMG-CoA reductase | 0.7 ± 0.1* |
---|---|---|
SREBP-1 | 0.6 ± 0.2* | |
SREBP-2 | n.c. | |
LDL receptor | 0.3 ± 0.06*** | |
FAS | 0.6 ± 0.1** | |
Cell proliferation | Cyclin D1 | 0.7 ± 0.2*** |
Cyclin B1 | 0.66 ± 0.3* | |
P21 | n.c. | |
EGFR | n.c. | |
Apoptosis | Caspase 2 | n.c. |
Caspase 3 | 1.5 ± 0.4** | |
Caspase 6 | 1.3 ± 0.2** | |
Caspase 7 | 3.9 ± 0.6*** | |
Caspase 9 | n.c. | |
Bax | 1.3 ± 0.3* | |
Bcl2 | 1.6 ± 0.4** | |
Mcl-1 | n.c. |