Figure 4

Cut-off calculations for predicting a pathological complete response (pCR) in the group of HER2-positive patients. The continuous line represents the -lg of the P value for each respective cut-off point relative to the percentage of Ki67-positive stained tumor cells. The dashed line represents the proportion of patients with a pCR in the group of patients with the higher Ki67 values for each cut-off. The gray background indicates the area for which cut-offs with a significance level of 0.05 is reached. For the maximum of each -lg (P value), the sample size and pCR rates are provided in the figure.