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Figure 5 | BMC Cancer

Figure 5

From: Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors

Figure 5

Mcl-1 siRNA downregulated Mcl-1 protein expression and markedly sensitized DLD1 and SW620 cells to MG132-mediated cell death. (A) Mcl-1 levels after treatment with siRNA ± MG132 in DLD1 cells. (B) Quantitative analysis of three western blot results. The value represents means ± SD. (C) MG132-mediated cell death in DLD1 and SW620 cells. Cells were pretreated with control siRNA or Mcl-1 siRNA for 24 h and then treated with 1 μM MG132 for another 24 h. DMSO was used as the mock control. Cell viability was determined in quadruplet and was normalized with cells treated with PBS alone, which was arbitrarily set as 1. The value represents means ± SD of a triplicate assay. * P < 0.01 compared with control siRNA+MG132.

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BMC Cancer

ISSN: 1471-2407

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