Figure 4
From: Role and expression of FRS2 and FRS3 in prostate cancer
Dual targeting of FRS2 and FRS3 is a global inhibitor of FGF induction. A and B: Migration experiments in PC3 and DU145 stimulated with different FGFs. C and D: Invasion assays for PC3 and DU145 cancer prostate cell lines in the presence of different FGFS and EGF. E: Silencing FRS2 and FRS3 inhibits FGF-simulated ERK activation of PC3 cells by FGF1 and FGF2 (*p < 0.005). siFRS2/3- siRNA against FRS2 and FRS3