| Total | HDAC1 low | HDAC1 high | p | HDAC2 low | HDAC2 high | p | HDAC3 low | HDAC3 high | p |
---|---|---|---|---|---|---|---|---|---|---|
All Cases | 163 | 70 (42.9%) | 93 (57.1%) | -- | 38 (23.3%) | 125 (76.7%) | -- | 32 (19.6%) | 131 (80.4%) | -- |
   VIN | 106 | 45 (42.5%) | 61 (57.5%) | 0.87 | 12 (11.3%) | 94 (88.7%) | < 0.001 | 28 (26.4%) | 78 (73.6%) | 0.003 |
   VSCC | 57 | 25 (43.9% | 32 (56.1%) |  | 26 (45.6%) | 31 (54.4%) |  | 4 (7.0%) | 53 (93.0%) |  |
   p16 neg | 39 | 17 (43.6%) | 22 (56.4%) | 1.00 | 10 (25.6%) | 29 (74.4%) | 0.67 | 4 (10.3%) | 35 (89.7%) | 0.109 |
   p16 pos | 124 | 53 (42.7%) | 71 (57.3%) |  | 28 (22.6%) | 96 (77.4%) |  | 28 (22.6%) | 96 (77.4%) |  |
   Age ≤ 60 | 93 | 41 (44.1%) | 52 (55.9%) | 0.752 | 22 (23.7%) | 71 (76.3%) | 1.00 | 21 (22.6%) | 72 (77.4%) | 0.322 |
   Age > 60 | 70 | 29 (41.4%) | 41 (58.6%) |  | 16 (22.9%) | 54 (77.1%) |  | 11 (15.7%) | 59 (84.3%) |  |
VSCC° |  |  |  |  |  |  |  |  |  |  |
   pT1 | 20 | 7 (35.0%) | 13 (65.0%) | 0.556* | 5 (25.0%) | 15 (75.0%) | 0.057* | 1 (5.0%) | 19 (95.0%) | 0.831* |
   pT2 | 24 | 11 (45.8%) | 13 (54.2%) |  | 13 (54.2%) | 11 (45.8%) |  | 2 (8.3%) | 22 (91.7%) |  |
   pT3 | 9 | 5 (55.6%) | 4 (44.4%) |  | 6 (66.7%) | 3 (33.3%) |  | 1 (11.1%) | 8 (88.9%) |  |
   pN0 | 23 | 9 (39.1%) | 14 (60.9%) | 0.763 | 9 (39.1%) | 14 (60.9%) | 0.366 | 1 (4.3%) | 22 (95.7%) | 1.00 |
   pN1/2 | 20 | 9 (45.0%) | 11 (55.0%) |  | 11 (55.0%) | 9 (45.0%) |  | 1 (5.0%) | 19 (95.0%) |  |
   G1 | 12 | 5 (41.7%) | 7 (58.3%) | 0.009* | 7 (58.3%) | 5 (41.7%) | 0.602* | 1 (8.3%) | 11 (91.7%) | 0.513* |
   G2 | 29 | 8 (27.6%) | 21 (72.4%) |  | 12 (41.4%) | 17 (58.6%) |  | 1 (3.4%) | 28 (96.6%) |  |
   G3 | 16 | 12 (75%) | 4 (25.0%) |  | 7 (43.8%) | 9 (56.3%) |  | 2 (12.5%) | 14 (87.5%) |  |
VIN | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Ki-67 ≤ 10% | 11 | 9 (81%) | 2 (18.2%) | 0.008 | 3 (27.3%) | 8 (72.7%) | 0.109 | 4 (36.4%) | 7 (63.6%) | 0.476 |
   Ki-67 > 10% | 95 | 36 (37.9%) | 59 (62.1%) |  | 9 (9.5%) | 86 (90.5%) |  | 24 (25.3%) | 71 (74.7%) |  |
VSCC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Ki-67 ≤ 10% | 19 | 8 (42.1%) | 11 (57.9%) | 1.00 | 14 (73.7%) | 5 (26.3%) | 0.004 | 2 (10.5%) | 17 (89.5%) | 0.594 |
   Ki-67 > 10% | 38 | 17 (44.7%) | 21 (55.3%) |  | 12 (31.6%) | 26 (68.4%) |  | 2 (5.3%) | 36 (94.7%) |  |