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Table 3 Interaction of the MTHFR C677T polymorphism and cigarette smoking or alcohol drinking

From: Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population

  Non-smokers Ever-smokers
Genotype Cases/ OR (95% CI) Cases/ OR (95% CI)
  Controls Crude P Adjusted* P Controls Crude P Adjusted* P
CC + CT 126/181 1.0 (reference) - 1.0 (reference) - 228/147 2.23 (1.64 - 3.03) <0.01 3.03 (2.12 - 4.34) <0.01
TT 27/28 1.39 (0.78 - 2.46) 0.28 1.95 (0.99 - 3.84) 0.05** 81/23 5.06 (3.02 - 8.47) <0.01 6.16 (3.48 - 10.9) <0.01
Crude Pinteraction = 0.21 and adjusted Pinteraction = 0.93
  Appropriate drinkers Excessive drinkers
Genotype Cases/ OR (95% CI) Cases/ OR (95% CI)
  Controls Crude P Adjusted* P Controls Crude P Adjusted* P
CC + CT 128/177 1.0 (reference) - 1.0 (reference) - 226/151 2.07 (1.52 - 2.81) <0.01 1.97 (1.38 - 2.82) <0.01
TT 50/27 2.56 (1.52 - 4.31) <0.01 2.46 (1.37 - 4.43) <0.01 58/24 3.34 (1.97 - 5.66) <0.01 3.09 (1.64 - 5.81) <0.01
Crude Pinteraction = 0.22 and adjusted Pinteraction = 0.30
  1. * Adjusted for age, sex, education and smoking or drinking.
  2. **Exact P = 0.053.