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Table 2 Association between the MTHFR polymorphisms and risk of lung cancer

From: Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population

 

Number (%) of

 

OR (95% CI)

Polymorphism

Cases

Controls

PHWE †

Crude

P

Adjusted*

P

C677T

       

CC (ancestral**)

153 (33.1)

158 (41.7)

 

1.0 (reference)

-

1.0 (reference)

-

CT

201 (43.5)

170 (44.9)

 

1.22 (0.90 - 1.65)

0.20

1.27 (0.90 - 1.80)

0.18

TT

108 (23.4)

51 (13.5)

0.62

2.19 (1.47 - 3.26)

<0.01

2.27 (1.42 - 3.62)

<0.01

Dominant model

CT + TT vs.CC

   

1.44 (1.09 - 1.91)

0.01

1.49 (1.08 - 2.07)

0.02

Recessive model

TT vs. CT + CC

   

1.96 (1.36 - 2.83)

<0.01

2.00 (1.30 - 3.07)

<0.01

A1298C

       

AA (ancestral**)

278 (60.2)

239 (63.1)

 

1.0 (reference)

-

1.0 (reference)

-

AC

154 (33.3)

122 (32.2)

 

1.08 (0.81 - 1.46)

0.59

0.97 (0.69 - 1.35)

0.84

CC

30 (6.49)

18 (4.75)

0.63

1.43 (0.78 - 2.64)

0.25

1.55 (0.76 - 3.17)

0.23

Dominant model

AC + CC vs. AA

   

1.13 (0.85 - 1.49)

0.39

1.03 (0.75 - 1.42)

0.85

Recessive model

CC vs. AC + AA

   

1.39 (0.76 - 2.54)

0.28

1.57 (0.77 - 3.18)

0.21

  1. * Adjusted for age, sex, education, smoking status and drinking.
  2. ** Defined by National Center for Biotechnology Information SNP database.
  3. † P for Hardy-Weinberg equilibrium test among controls.
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BMC Cancer

ISSN: 1471-2407

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