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Table 2 Association between the MTHFR polymorphisms and risk of lung cancer

From: Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population

  Number (%) of   OR (95% CI)
Polymorphism Cases Controls PHWE Crude P Adjusted* P
C677T        
CC (ancestral**) 153 (33.1) 158 (41.7)   1.0 (reference) - 1.0 (reference) -
CT 201 (43.5) 170 (44.9)   1.22 (0.90 - 1.65) 0.20 1.27 (0.90 - 1.80) 0.18
TT 108 (23.4) 51 (13.5) 0.62 2.19 (1.47 - 3.26) <0.01 2.27 (1.42 - 3.62) <0.01
Dominant model
CT + TT vs.CC
    1.44 (1.09 - 1.91) 0.01 1.49 (1.08 - 2.07) 0.02
Recessive model
TT vs. CT + CC
    1.96 (1.36 - 2.83) <0.01 2.00 (1.30 - 3.07) <0.01
A1298C        
AA (ancestral**) 278 (60.2) 239 (63.1)   1.0 (reference) - 1.0 (reference) -
AC 154 (33.3) 122 (32.2)   1.08 (0.81 - 1.46) 0.59 0.97 (0.69 - 1.35) 0.84
CC 30 (6.49) 18 (4.75) 0.63 1.43 (0.78 - 2.64) 0.25 1.55 (0.76 - 3.17) 0.23
Dominant model
AC + CC vs. AA
    1.13 (0.85 - 1.49) 0.39 1.03 (0.75 - 1.42) 0.85
Recessive model
CC vs. AC + AA
    1.39 (0.76 - 2.54) 0.28 1.57 (0.77 - 3.18) 0.21
  1. * Adjusted for age, sex, education, smoking status and drinking.
  2. ** Defined by National Center for Biotechnology Information SNP database.
  3. P for Hardy-Weinberg equilibrium test among controls.