Figure 1
Effects of magnolol pretreatment on tumor incidence, tumor multiplicity and tumor area in UVB-induced skin carcinogenesis in SKH-1 mice. (A) Effects of topical magnolol pretreatment on tumor incidence. From the 20th week to the end of the experiment magnolol 30 μ g and 60 μ g reduced significantly tumor incidence. Each point represents the percentage of animals bearing at least one tumor, values derived from 20 mice. *Significant difference (p < 0.05). (B) Effects of magnolol pretreatment on tumor multiplicity. Magnolol 30 and 60 μ g pretreatment significantly decreased tumor multiplicities from the 16th to 25th week of UVB induced carcinogenesis. Each point represents mean number of tumors per mouse ± SE derived from 20 mice. *Significant difference (p < 0.05). (C) Effects of magnolol treatment on tumor area. Average ratio of total tumor area to total back area of the SKH-1 mice. Each bar represents mean ratio of tumor area per mouse ± SE derived from 20 mice.* Significant difference (p < 0.05)