Figure 4

Normal-to-tumor histone modification transitions. (A) Normal-to-tumor transition graphs detected in patient 1 separated by starting condition. The number of associated genes is given below each of the 15 monitored transitions. The 15 transitions are grouped into 3 categories given by the color of the target. Below each start condition a region-centered footprint is drawn depicting the change in signal over the detected genomic regions. The selected transitions are highlighted in bold in the graph. (B) Part of the WNT-pathway color coded by change in epigenetic markers in patient 1. Red indicate an activating change ('N -' to 'T K4', 'N K27' to 'T K4' or 'N Biv' to 'T K4') while Blue indicate an repressive change ('N -' to 'T K27', 'N K4' to 'T K27', 'N K4' to 'T -', 'N K4' to 'T Biv' or 'N Biv' to 'T K27').