Figure 5
From: Effects of EpCAM overexpression on human breast cancer cell lines
Docetaxel sensitivity testing. Hs578TEpCAM and Hs578Tcontrol cells (A) as well as MDA-MB-231EpCAM and MDA-MB-231control (B) cells have been treated one day after seeding with different amounts of the chemotherapeutic Docetaxel for 24 hours. Sensitivity to the chemotherapeutic was evaluated in % proliferation (±SEM) with 100% proliferation for untreated cells. Hs578TEpCAM cells were more sensitive to Docetaxel treatment as compared to their EpCAM negative counterpart Hs578Tcontrol, whereas no difference in sensitivity could be detected in MDA-MB-231 transfectants. Docetaxel is known to inhibit mitosis by blocking the microtubule apparatus, therefore we suggest that the enhanced sensitivity of Hs578TEpCAM cells can be related to their enhanced proliferation rate.