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Table 5 Specificity and sensitivity values for various intraoperative margin assessment methods

From: High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: a feasibility study

Method and references Specificity Sensitivity
Touch preparation cytology [45, 46] 83-100% 75-96%
Frozen section analysis [5, 47, 48] 92-100% 65-78%
Near-field RF spectroscopy [49] 70% 70%
Raman spectroscopy [50] 93% 83%
Optical coherence tomography [11] 82% 100%
Fluorescence and reflectance spectroscopy [51] 96% 85%
Low-freq. (2-10 MHz) ultrasonic attenuation [27] 90% 80%
  1. Values represent comparison between normal vs. malignant tissue.