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Table 1 Chemotherapic agents used in the present study

From: Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines

    Clinical dose Half time In vivo AUC72 hr In vitro used concentrations In vitro AUC72 hr Ref QAUC
Antimetabolites Folic acid Methotrexate 12 g/m2 24 623,70 0,033 - 4,17 12,000-1499,976 [21] 0,019 - 2,405
  Purine Cladribine 5 mg/m2 3 5,67 0,007 - 0,83 0,480-59,976 [22] 0,085-10,578
   Fludarabine 25 mg/m2 2 27,72 0,167 - 20,83 12,000-1499,976 [23] 0,433-54,112
   6-Mercaptopurin 85 mg/m2 4 138,60 0,556 - 69,44 39,997-4999,680 [24] 0,289-36,073
  Pyrimidine Cytarabine 1 g/m2 2 221,76 0,133 - 16,66 9,596-1199,520 [25] 0,043-5,409
   Fluorouracil 400 mg/m2 0.25 69,30 0,333 - 41,66 23,996-2999,520 [26] 0,346-43,283
   Gemcitabine 1000 mg/m2 0.7 388,08 0,267 - 33,33 19,198-2399,760 [27] 0,049-6,184
Alkylating/alkylating-like Nitrogen mustards Chlorambucil 0.2 mg/m2 2 33,60 0,667 - 83,33 47,998-5999,760 [28] 1,429-178,564
  Platinum Carboplatin 360 mg/m2 3 665,28 0,007 - 0,83 0,480-59,976 [29] 0,001-0,090
   Oxaliplatin 130 mg/m2 5.74 270,46 0,033 - 4,17 2,400-299,952 [30] 0,009-1,109
Spindle poison/mitotic inhibitor Taxane Docetaxel 85 mg/m2 0.6 24,95 0,067 - 8,33 4,798-599,760 [31] 0,192-24,040
   Paclitaxel 175 mg/m2 3 257,80 0,013 - 1,67 0,956-119,520 [27] 0,004-0,464
  Vinca Vinblastin 1.7 mg/m2 0.83 1,71 0,00067 - 0,083 0,048-5,998 [32] 0,028-3,510
   Vincristine 1.32 mg/m2 2 1,55 0,00067 - 0,083 0,480-59,976 [33] 0,309-38,636
   Vinorelbine 80 mg/m2 40 498,96 0,007 - 0,83 4,798-599,760 [34] 0,010-1,202
Cytotoxic/antitumor antibiotics Anthracyclin Daunorubicin 1.5 mg/kg 18 531,56 0,033 - 4,17 2,400-299,952 [35] 0,005-0,564
   Doxorubicin 50 mg/m2 30 1091,48 0,013 - 1,66 0,956-119,520 [36] 0,001-0,110
   Epirubicin 90 mg/m2 15 604,21 0,013 - 1,66 0,960-119,952 [27] 0,002-0,199
  Streptomyces Dactinomycin 1.5 mg/m2 36 8,98 0,003 - 0,42 0,240-29,995 [37] 0,027-3,340
   Bleomycin 8 IU/kg/day 6 33,26 0,008 - 1 0,576-72,000 [38] 0,017-2,165
   Mitomycin 20 mg/m2 1 4,44 0,003 - 0,33 0,317-39,600 [39] 0,071-8,929
   Hydroxyurea 15 mg/m2 2 630,00 0,333 - 41,66 23,996-2999,520 [40] 0,038-4,761
Topo-isomerase in-hibitors Camptotheca Topotecan 1.2 mg/m2 3 2,49 0,007 - 0,83 0,054-6,718 [41] 0,022-2,693
   Etoposide 100 mg/m2 4 221,76 0,133 - 16,66 9,596-1199,520 [25] 0,043-5,409
Other   Asparaginase 30000 IU/m2 8 26,56 0,033 - 4,17 2,400-299,952 [42] 0,090-11,294
   Bortezomib 1.45 mg/m2 40 21,62 0,007 - 0,83 0,480-59,976 [43] 0,022-2,774
   Prednisolone 1 mg/kg/day 3 41.58 0,16666 - 20,83 11,998-1499,760 [44] 0,289-36,069