Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

BMC Cancer

Table 2 Counts of events in patients with colorectal cancer treated with curative intention (n = 332).

Years from diagnosis	1	2	3	4	5	6	7	8
Number entering the interval	332	305	286	261	242	221	209	156
Type of event in numbers									Total
Locoregional recurrence	1	2	0	0	1	0	0	0	4
Distant metastases	13	20	13	10	6	2	2	0	66
Second primary, same cancer	0	2	1	1	0	0	0	0	4
Second primary, other cancer	2	4	6	5	4	3	1	1	26
Death from same cancer	6	10	13	12	8	3	6	1	59
Death from other cancer	1*	0	1*	1	0	2	0	0	5
Non - cancer-related death	14	9	11	6	12	7	7	8	74
Treatment-related death	6	0	0	0	0	0	0		6
Loss to follow-up	0	0	0	1	0	0	0		1
Number of events for each type of survival endpoint
DFS	36	35	29	18	22	12	10	8	170
RFS	34	29	25	16	18	9	4	4	139
OS	27	19	25	19	20	12	13	9	144
TTF	20	22	15	11	6	4	2	0	80
TTR	14	20	13	10	7	2	2	0	68
CSS	6	10	13	12	8	3	6	1	59
Cumulative number of events at 3 and 5 years n
DFS			100		140				155
OS			71		110				125

Numbers are presented up to 8 years of follow-up.
* Death from other cancer diagnosed before the primary CRC. DFS: disease-free survival; RFS: relapse-free survival; TTF: time to treatment failure; TTR: time to recurrence; CSS: cancer-specific survival; OS: overall survival

ISSN: 1471-2407