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Table 1 Definition of endpoints and events as suggested by the consensus agreement of Punt et al. J Natl Cancer Inst 2007; 99(13): 998-1003.

From: Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

  

Endpoint

   

Event

DFS

RFS

TTR

TTF

CSS

OS

Locoregional recurrence

E

E

E

E

I

I

Distant metastases

E

E

E

E

I

I

Second primary, same cancer

E

I

I

E

I

I

Second primary, other cancer

E

I

I

E

I

I

Death from same cancer

E

E

E

E

E

E

Death from other cancer

E

E

C

E

C

E

Non - cancer-related death

E

E

C

C

C

E

Treatment-related death

E

E

C

E

C

E

Loss to follow-up

C

C

C

C

C

C

  1. DFS = disease-free survival; RFS = relapse-free survival; TTR = time to recurrence; TTF = time to treatment failure; CSS = cancer specific survival; OS = overall survival; E = event; C = censor; I = ignore