Skip to main content

Table 4 Univariate and multivariate analysis according to stage

From: Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

Characteristics Hazard ratio (95% CI)
in univariate analysis
P value* Hazard ratio (95% CI)
in multivariate analysis
P value*
AJCC stage I     
Serum AFP (≥ 400 ng/mL) 1.523 (0.412-5.629) 0.528 1.490 (0.394-5.649) 0.556
Serum PIVKA-II (≥ 300 mAU/mL) 9.317 (2.736-30.453) < 0.001 8.771 (2.538-30.303) 0.001
PT (≤ 80%) 1.862 (0.503-6.896) 0.352 0.746 (0.164-3.397) 0.705
Platelet count (≤ 130 × 103/μL) 4.608 (1.250-16.949) 0.022 4.948 (1.097-22.322) 0.037
AJCC stage II     
Serum AFP (≥ 400 ng/mL) 3.484 (1.233-9.803) 0.018 2.832 (0.983-8.196) 0.054
Serum PIVKA-II (≥ 300 mAU/mL) 3.984 (1.466-10.989) 0.008 3.355 (1.179-9.523) 0.023
PT (≤ 80%) 1.198 (0.434-3.305) 0.728 1.167 (0.382-3.564) 0.786
Platelet count (≤ 130 × 103/μL) 1.164 (1.413-3.267) 0.773 0.820 (0.265-2.542) 0.732
AJCC stage III     
Serum AFP (≥ 400 ng/mL) 1.037 (0.586-1.834) 0.899 1, 164 (0.652-2.078) 0.608
Serum PIVKA-II (≥ 300 mAU/mL) 2.252 (1.116-4.545) 0.023 2.212 (1.086-4.504) 0.028
PT (≤ 80%) 1.192 (0.659-2, 158) 0.561 1.254 (0.685-2.296) 0.464
Platelet count (≤ 130 × 103/μL) 1.934 (1.062-3.522) 0.031 1.868 (1.017-3.428) 0.044
BCLC stage A     
Serum AFP (≥ 400 ng/mL) 1.934 (1.094-3.424) 0.023 2.544 (1.003-6.451) 0.049
Serum PIVKA-II (≥ 300 mAU/mL) 9.319 (3.856-22.525) < 0.001 8.403 (3.424-20.408) < 0.001
PT (≤ 80%) 1.845 (0.714-4.761) 0.206 1.098 (0.404-2.9984) 0.854
Platelet count (≤ 130 × 103/μL) 2.127 (0.896-5.050) 0.087 2.055 (0.820-5.153) 0.125
BCLC stage B     
Serum AFP (≥ 400 ng/mL) 1.183 (0.502-2.791) 0.701 1.163 (0.482-2.807) 0.737
Serum PIVKA-II (≥ 300 mAU/mL) 1.740 (0.715-4.232) 0.222 1.743 (0.711-4.271) 0.225
PT (≤ 80%) 1.054 (0.443-2.508) 0.905 1.142 (0.448-2.911) 0.782
Platelet count (≤ 130 × 103/μL) 1.243 (0.461-2.710) 0.804 1.072 (0.424-2.712) 0.833
BCLC stage C     
Serum AFP (≥ 400 ng/mL) 1.382 (0.656-2.910) 0.394 1.377 (0.610-3.105) 0.440
Serum PIVKA-II (≥ 300 AU/mL) 2.909 (1.015-8.333) 0.047 3.174 (1.098-9.174) 0.033
PT (≤ 80%) 0.800 (0385-1.659) 0.548 0.588 (0.258-1.338) 0.205
Platelet count (≤ 130 × 103/μL) 1.642 (0.790-3.412) 0.184 1.917 (0.893-4.114) 0.095
  1. Abbreviation: AFP, alpha-fetoprotein; PIVKA-II, Protein induced by vitamin K absence or antagonist-II; PT, prothrombin time.
  2. *P-values for each clinical variable calculated using Cox regression analysis.