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Table 2 Univariate analysis in overall patients

From: Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

Characteristics

Hazard ratio (95% CI)

P value*

Age (years)

0.981 (0.958-1.004)

0.106

Sex

0.937 (0.558-1.576)

0.807

Etiology of CLD

0.361 (0.090-1.439)

0.149

Portal vein thrombosis

6.716 (4.169-10.819)

< 0.001

Child-Pugh class

1.264 (0.833-1.918)

0.270

AJCC Tumor stage

4.759 (3.410-6.643)

< 0.001

BCLC Tumor stage

1.532 (1.383-1.698)

< 0.001

Serum AFP

1.0000007

(1.0000002-1.0000013)

0.008

Serum AFP (≥ 400 ng/mL)

3.666 (2.332-5.762)

< 0.001

Serum PIVKA-II

1.000102

(1.00007-1.00012)

< 0.001

Serum PIVKA-II (≥ 300 mAU/mL)

8.701 (5.394-14.035)

< 0.001

Platelet count (≤ 130 × 103/μL)

2.319 (1.454-3.698)

0.0004

PT (≤ 80%)

0.737 (0.460-1.179)

0.203

Albumin (≥ 3.5 g/dl)

0.790 (0.498-1.252)

0.316

Total bilirubin (≥ 1.5 mg/dL)

1.174 (0.287-4.796)

0.823

  1. Values in the column are represented as number of patients (%) or median value (range).
  2. Abbreviation: CLD, chronic liver disease; AFP, alpha-fetoprotein; PIVKA-II, Protein induced by vitamin K absence or antagonist-II; PT, prothrombin time; AST, aspartate aminotransaminase; ALT, alanine aminotransferase.
  3. *P-values for each clinical variable calculated using Cox regression analysis.
  4. †all were used with continuous variables.