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Table 2 Univariate analysis in overall patients

From: Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

Characteristics Hazard ratio (95% CI) P value*
Age (years) 0.981 (0.958-1.004) 0.106
Sex 0.937 (0.558-1.576) 0.807
Etiology of CLD 0.361 (0.090-1.439) 0.149
Portal vein thrombosis 6.716 (4.169-10.819) < 0.001
Child-Pugh class 1.264 (0.833-1.918) 0.270
AJCC Tumor stage 4.759 (3.410-6.643) < 0.001
BCLC Tumor stage 1.532 (1.383-1.698) < 0.001
Serum AFP 1.0000007
(1.0000002-1.0000013)
0.008
Serum AFP (≥ 400 ng/mL) 3.666 (2.332-5.762) < 0.001
Serum PIVKA-II 1.000102
(1.00007-1.00012)
< 0.001
Serum PIVKA-II (≥ 300 mAU/mL) 8.701 (5.394-14.035) < 0.001
Platelet count (≤ 130 × 103/μL) 2.319 (1.454-3.698) 0.0004
PT (≤ 80%) 0.737 (0.460-1.179) 0.203
Albumin (≥ 3.5 g/dl) 0.790 (0.498-1.252) 0.316
Total bilirubin (≥ 1.5 mg/dL) 1.174 (0.287-4.796) 0.823
  1. Values in the column are represented as number of patients (%) or median value (range).
  2. Abbreviation: CLD, chronic liver disease; AFP, alpha-fetoprotein; PIVKA-II, Protein induced by vitamin K absence or antagonist-II; PT, prothrombin time; AST, aspartate aminotransaminase; ALT, alanine aminotransferase.
  3. *P-values for each clinical variable calculated using Cox regression analysis.
  4. †all were used with continuous variables.