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Table 3 Comparison of sensitivity of single and double FIT sampling for screen relevant neoplasia, at fixed specificities

From: Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study

  Single FIT   "one of two FITs+"    "two of two FITs+"    "mean of two FITs+"   
Spec Sens Cut-off Sens Cut-off p-value Sens Cut-off p-value Sens Cut-off p-value
85% 51, 6% 34 53, 2% 59 1 n.a.* n.a.* n.a.* 53, 2% 40 1
90% 46, 0% 73 51, 6% 103 0, 07 44, 4% 27 0, 687 50, 8% 60 0, 125
95% 38, 7% 184 37, 9% 371 1 41, 1% 91 0, 453 37, 9% 159 1
  1. Corresponding cut-off values (ng/ml) and sensitivities for screen relevant neoplasia of single FIT sampling and three different strategies of double FIT sampling at fixed specificities of 85%, 90% and 95%.
  2. FIT = faecal immunochemical test, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, spec = specificity, sens = sensitivity, cut-off = cut-off value, n.a.* = no corresponding sensitivity and cut-off value found in the range 50-200 ng/ml