Table 8 Correlations between drug exposure and toxicity, normalised drug exposure and creatinine clearance (Spearman rank order analysis).
Exposure | platelets†| neutrophils†| CrCl‡ |
|---|---|---|---|
Dose | -0.79 (2 × 10-7) | -0.56 (5 × 10-3) | - |
PR-104 AUC | -0.56 (0.005) | -0.35 (0.1) | -0.14 (0.52) |
PR-104A AUC | -0.75 (2 × 10-7) | -0.49 (0.02) | -0.12 (0.59) |
PR-104G AUC | -0.51 (0.01) | -0.13 (0.56) | -0.01 (0.98) |
PR-104(H+M) AUC | 0.09 (0.67) | -0.04 (0.84) | -0.04 (0.86) |
PR-104S1 AUC | -0.61 (0.002) | -0.53 (0.009) | -0.16 (0.46) |