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Table 8 Correlations between drug exposure and toxicity, normalised drug exposure and creatinine clearance (Spearman rank order analysis).

From: A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

Exposure platelets neutrophils CrCl
Dose -0.79 (2 × 10-7) -0.56 (5 × 10-3) -
PR-104 AUC -0.56 (0.005) -0.35 (0.1) -0.14 (0.52)
PR-104A AUC -0.75 (2 × 10-7) -0.49 (0.02) -0.12 (0.59)
PR-104G AUC -0.51 (0.01) -0.13 (0.56) -0.01 (0.98)
PR-104(H+M) AUC 0.09 (0.67) -0.04 (0.84) -0.04 (0.86)
PR-104S1 AUC -0.61 (0.002) -0.53 (0.009) -0.16 (0.46)
  1. At nadir (percentage of pretreatment value)
  2. Creatinine clearance. Drug exposures (AUC) are normalised by dose levels.
  3. Values are correlation coefficient and (p value).