Table 5 PR-104 and PR-104A plasma pharmacokinetic parameters for cycle 1 day 1
|  |  |  | Cmax(μM) | AUC (μM.h) | t1/2(h) | Cl (L/h/m2) | Vdss(L/m2) | |||
|---|---|---|---|---|---|---|---|---|---|---|
Dose-level (mg/m2) | Â | n | PR-104 | PR-104A | PR-104 | PR-104A | PR-104 | PR-104A | PR-104 | PR-104 |
135 | Â | 2 | 4.08 | 3.49 | 2.85 | 3.22 | 0.06 | 0.34 | 128 | 38.7 |
270 | Â | 6 | 7.63 (3.13) | 6.81 (2.15) | 4.15 (1.69) | 6.61 (2.88) | 0.07 (0.05) | 0.42 (0.16) | 129 (49.4) | 39.1 (9.83) |
540 | Â | 6 | 14.2 (6.51) | 13.7 (2.94) | 9.34 (4.17) | 14.0 (2.70) | 0.07 (0.03) | 0.42 (0.16) | 130 (119) | 44.7 (38.5) |
675 | Â | 7 | 18.1 (9.9) | 15.5 (6.1) | 12.9 (7.0) | 17.7 (5.6) | 0.14 (0.10) | 0.55 (0.11) | 92.7 (52.2) | 27.3 (14.4) |
900 | Â | 4 | 20.8 (5.71) | 23.3 (4.64) | 15.2 (4.97) | 29.5 (8.44) | 0.15 (0.10) | 0.68 (0.14) | 64.8 (22.9) | 24.2 (10.5) |