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Table 3 Haematological toxicity

From: A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

Worst toxicity severity grade of haematological toxicity by patient (number of patients (%))
Dose level 135 mg/m2 270 mg/m2 540 mg/m2 675 mg/m2 900 mg/m2 All doses
Number of patients n = 3 n = 6 n = 6 n = 7 n = 4 n = 26
Toxicity severity grade 2 3 4 2 3 4 2 3 4 2 3 4 2 3 4 2 3 4
Anaemia 1 (33) 1 (33)   2 (33) 1 (17)   4 (67) 1 (17)   4 (57) 1 (14) 1 (14) 2 (50) 2 (50)   13 (50) 6 (23) 1 (14)
Leukopenia     1 (17)    2 (33) 1 (17)   3 (43) 2 (29)   2 (50) 1 (25)   8 (31) 4 (15)  
Neutropenia     1 (17)    2 (33) 1 (17)   2 (29) 1 (14)     3 (75) 5 (19) 2 (8) 3 (12)
Thrombocytopenia     1 (17)    1 (17) 1 (17) 1 (17) 1 (14) 2 (29)    1 (25) 2 (50) 3 (12) 4 (15) 2 (8)
Any haematological toxicity 1 (33) 1 (33)   3 (50) 1 (17)   3 (50) 2 (33) 1 (17) 4 (57) 2 (29) 1 (14)    4 (100) 11 (42) 6 (23) 6 (23)