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Table 2 Prostate cancer risk by subgroups

From: Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up

 

Full cohort

Genotyped men

 

NonPrCa*

PrCa

PrCa-risk

NonPrCa

PrCa

PrCa-risk

Serum selenium(μg/l)

N

%

N

%

RR**

95% CI***

N

%

N

%

RR

95% CI

≤70

675

(36.7)

84

(40.4)

Ref

-

295

(33.6)

48

(38.1)

Ref

-

70.1-81.0

588

(32.0)

65

(31.2)

0.89

(0.65 - 1.24)

299

(34.0)

46

(35.7)

0.93

(0.62 - 1.4)

81+

574

(31.2)

59

(28.4)

0.83

(0.60 - 1.16)

285

(32.4)

33

(26.2)

0.72

(0.46 - 1.12)

Erythrocyte sedimentation rate, ESR(mm/h)

≤4.0

704

(38.3)

84

(40.4)

Ref

-

348

(39.6)

51

(40.5)

Ref

-

4.1-8.0

587

(32.0)

67

(32.2)

0.97

(0.70 - 1.33)

297

(33.8)

38

(30.2)

0.89

(0.58 - 1.35)

8+

545

(29.7)

57

(27.4)

0.88

(0.63 - 1.23)

234

(26.6)

37

(29.4)

1.07

(0.7 - 1.62)

Total serum cholesterol(mmol/l)

≤6.24

560

(30.5)

76

(36.5)

Ref

-

288

(32.8)

48

(38.1)

Ref

-

6.25-7.27

624

(34.0)

64

(30.8)

0.77

(0.55 - 1.07)

295

(33.6)

40

(31.7)

0.82

(0.54 - 1.25)

7.27+

653

(35.5)

68

(32.7)

0.78

(0.56 - 1.08)

296

(33.7)

38

(30.2)

0.78

(0.51- 1.19)

BMI(kg/m 2 )

≤23.4

605

(32.9)

61

(29.3)

Ref

-

296

(33.7)

39

(31.0)

Ref

-

23.5-26.0

567

(30.9)

78

(37.5)

1.34

(0.96 - 1.87)

285

(32.4)

50

(39.7)

1.31

(0.86 - 1.99)

26+

665

(36.2)

69

(33.2)

1.03

(0.73 - 1.46)

298

(33.9)

37

(29.4)

0.96

(0.61 - 1.5)

Smoking

non-smoker

449

(24.4)

69

(33.2)

Ref

-

258

(29.4)

45

(35.7)

Ref

-

smoker

961

(52.3)

86

(41.3)

0.6

(0.44 - 0.83)

394

(44.8)

47

(37.3)

0.70

(0.46 - 1.05)

ex-smoker

427

(23.2)

53

(25.5)

0.82

(0.58 - 1.18)

227

(25.8)

34

(27.0)

0.87

(0.56 - 1.36)

  1. Unadjusted relative risk (RR) of prostate cancer (PrCa) for baseline tertiles of selenium with 95% confidence intervals (CI), the two selenium level modifying factors ESR, total cholesterol, BMI and for smoking status in the full cohort and in the genotyped men. The lowest tertiles and the non-smokers were used as references.
  2. * Prostate cancer
  3. ** Relative risk
  4. *** Confidence interval