Histopathology of LNCaP xenograft prostate tumors. (a) Photograph of tumor (at 20× magnification), injected with medium shows an irregular expansible growth and compression (marked as C) of adjacent normal tissue, revascularization (marked as NV) and vascular metastasis (marked as M). (b) 100× magnification of the upper square in panel-a (solid-line boundary for the demarcated box), showing prominent vascular metastasis (M). (c) 400× magnification of the lower dashed square (demarcated by the broken-line boundary) in panel-a, showing a typical mitotic figure (see arrow). (d) Photograph (at 20X) of RSV-injected tumor. Tumor size is markedly reduced and complete necrosis of the neoplastic cells with minimal fibrovascular encapsulation and pyogranulamatous inflammation is evident. Marked necrosis at the center of the tumor is readily apparent. (e) 100× magnification and (f) 400× magnification of the solid-line square in panel-d, highlighting minimal fibrovascular encapsulation, FV (panel-e) and complete tumor necrosis, TN (panel-f). NT: normal tissue. ND: non-tumor debris.