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Figure 6 | BMC Cancer

Figure 6

From: MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo

Figure 6

Repressing TP53INP1 could significantly attenuate the inhibitory effect of miR-125bi on type II EC cell proliferation and migration. A~B. The expression level of TP53INP1 protein was detected by western blot at 48 h posttransfection and normalized to that of β-actin. The expression level of TP53INP1 protein was significantly lower in cells cotransfected with miR-125bi plus siTP53INP1 as compared to the cells cotransfected with the same inhibitors plus siTP53INP1 control (*P < 0.01). C. Cell proliferation was evaluated by CCK8 analysis. The proliferative capacity of AN3CA cells cotransfected with miR-125bi plus siTP53INP1 was significantly higher than that of cells cotransfected with miR-125bi plus siTP53INP1 control (*P < 0.05). D. Cell migration ability of AN3CA was determined by transwell migration analysis. The number of migrated cells of AN3CA cells cotransfected with miR-125bi plus siTP53INP1 was increased about 2.5 fold as compared that of cells cotransfected with miR-125bi plus siTP53INP1 control (*P < 0.01).

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BMC Cancer

ISSN: 1471-2407

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