Activating mutation in MET oncogene in familial colorectal cancer

BMC Cancer

Table 2 Cancer cases with MET mutations

Sample*	Mutation	Age	Stage	Grade - differentiation	Colonic location	Relative copy number c.2975T (Tumor/Normal)
sib1	V136I	87	3	moderately well	transverse	ND
sib2	E168D	71	3	moderately well	splenic flexure	ND
sib3-A	T992I	52	2	well	rectosigmoid	1.60
sib4-A	T992I	62	1	moderately well	ascending	4.32
sib5	T992I	44	3	poorly	rectosigmoid	1.84
sib6-B	T992I	66	1	not reported	descending	1.79
sib7-B	T992I	66	1	not reported	descending	0.07
sib8-C	T992I	68	2	moderately well	cecum	0.31
sib9-C	T992I	75	1	moderately well	descending	0.38
hr10-D	T992I	71	4	moderate	cecum	0.06
hr11	T992I	60	1	moderate	splenic flexure	0.10
hr12	T992I	51	2	moderate	descending	0.34
hr13	T992I	77	2	well	sigmoid	0.05
hr14	T992I	89	2	moderate	rectum	2.55
hr15	T992I	35	2	moderate	transverse	1.56
hr16-D	T992I	47	4	moderate well	cecum	ND
hr17	T992I	68	3	moderate to focally poor	sigmoid	0.05
hr18	T992I	50	4	moderate	rectum	0.11

*sib indicates patient from sibling pair cohort, hr indicates patient from high risk cohort, -letter indicates same family. Not done (ND).

ISSN: 1471-2407