Skip to main content

Table 2 Cancer cases with MET mutations

From: Activating mutation in MET oncogene in familial colorectal cancer

Sample* Mutation Age Stage Grade - differentiation Colonic location Relative copy number c.2975T (Tumor/Normal)
sib1 V136I 87 3 moderately well transverse ND
sib2 E168D 71 3 moderately well splenic flexure ND
sib3-A T992I 52 2 well rectosigmoid 1.60
sib4-A T992I 62 1 moderately well ascending 4.32
sib5 T992I 44 3 poorly rectosigmoid 1.84
sib6-B T992I 66 1 not reported descending 1.79
sib7-B T992I 66 1 not reported descending 0.07
sib8-C T992I 68 2 moderately well cecum 0.31
sib9-C T992I 75 1 moderately well descending 0.38
hr10-D T992I 71 4 moderate cecum 0.06
hr11 T992I 60 1 moderate splenic flexure 0.10
hr12 T992I 51 2 moderate descending 0.34
hr13 T992I 77 2 well sigmoid 0.05
hr14 T992I 89 2 moderate rectum 2.55
hr15 T992I 35 2 moderate transverse 1.56
hr16-D T992I 47 4 moderate well cecum ND
hr17 T992I 68 3 moderate to focally poor sigmoid 0.05
hr18 T992I 50 4 moderate rectum 0.11
  1. *sib indicates patient from sibling pair cohort, hr indicates patient from high risk cohort, -letter indicates same family. Not done (ND).