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Table 4 Comparisons of the CD44 isoform mRNA levels in tumors of different clinical characteristics.

From: CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

 

n (%)

CD44

v2-v102

P1

CD44

v3-v102

P1

CD44

v8-v102

P1

CD44

standard2

P1

CD44

total2

P1

Age

180

1.645

 

1.276

 

1.340

 

0.295

 

0.736

 

   < 50 years

47 (26)

1.432

0.0063

1.228

0.23

1.615

0.12

0.250

0.32

0.732

0.42

   ≥50 years

133 (74)

1.733

 

1.281

 

1.301

 

0.311

 

0.749

 

Tumor size

167

1.664

 

1.257

 

1.303

 

0.294

 

0.734

 

   ≤20 mm

46 (28)

1.791

0.22

1.311

0.48

1.547

0.41

0.398

0.0027

0.802

0.071

   > 20 mm

121 (72)

1.638

 

1.248

 

1.258

 

0.271

 

0.720

 

Lymph node status

166

1.666

 

1.264

 

1.308

 

0.295

 

0.734

 

   Negative (n = 0)

52 (31)

1.591

0.25

1.221

0.65

1.349

0.060

0.273

0.14

0.740

0.96

   Positive (n > 0)

114 (69)

1.727

 

1.287

 

1.276

 

0.321

 

0.732

 

S-phase fraction

119

1.682

 

1.281

 

1.354

 

0.281

 

0.745

 

   Low (< 12%)

75 (63)

1.859

0.0001

1.347

0.0021

1.322

0.86

0.283

0.92

0.802

0.0014

   High (≥12%)

44 (37)

1.404

 

1.163

 

1.368

 

0.265

 

0.621

 

ER

180

1.650

 

1.243

 

1.322

 

0.300

 

0.736

 

   Negative (< 25 fmol/mg)

86 (48)

1.461

0.0020

1.142

0.0018

1.440

0.32

0.309

0.53

0.706

0.086

   Positive (≥25 fmol/mg)

94 (52)

1.834

 

1.361

 

1.272

 

0.288

 

0.767

 

PgR

178

1.601

 

1.243

 

1.323

 

0.297

 

0.736

 

   Negative (< 25 fmol/mg)

107 (60)

1.562

0.0024

1.151

0.0007

1.355

0.87

0.299

0.53

0.723

0.17

   Positive (≥25 fmol/mg)

71 (40)

1.875

 

1.461

 

1.303

 

0.293

 

0.771

 

HER2

82

1.716

 

1.231

 

1.343

 

0.257

 

0.708

 

   Weak/negative

63 (77)

1.759

0.26

1.290

0.022

1.544

0.014

0.230

0.0016

0.737

0.054

   Strong (score = 3)

19 (23)

1.594

 

1.139

 

1.115

 

0.442

 

0.682

 

EGFR

69

1.664

 

1.237

 

1.312

 

0.254

 

0.712

 

   Weak/negative

58 (84)

1.686

0.97

1.236

0.56

1.284

0.032

0.257

0.34

0.708

0.43

   Strong (score≥7)

11 (16)

1.580

 

1.237

 

1.734

 

0.202

 

0.818

 

PTEN

110

1.675

 

1.276

 

1.347

 

0.269

 

0.730

 

   Negative

34 (31)

1.586

0.22

1.182

0.18

1.337

0.98

0.309

0.16

0.692

0.34

   Positive

76 (69)

1.727

 

1.322

 

1.347

 

0.241

 

0.739

 

PIK3CA

107

1.669

 

1.270

 

1.312

 

0.271

 

0.715

 

   Wildtype

76 (71)

1.589

0.0036

1.233

0.075

1.398

0.15

0.281

0.78

0.714

0.40

   Mutation

31 (29)

1.965

 

1.355

 

1.178

 

0.249

 

0.752

 

Distant metastasis

149

1.733

 

1.287

 

1.292

 

0.293

 

0.744

 

   Negative

99 (66)

1.837

0.12

1.328

0.15

1.292

0.73

0.284

0.52

0.752

0.27

   Positive

50 (33)

1.618

 

1.199

 

1.294

 

0.304

 

0.726

 
  1. 1 Mann-Whitney test
  2. 2 Median values
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