Time- and dose-dependent effects of the MK-0457 on TT cell proliferation. The TT cells were cultured in absence (DMSO) or in presence of 200 nM MK-0457 for different periods of time (A) or with different concentrations of MK-0457 (5 nM - 1000 nM) for 6 days (B). Data reported are representative of one out of three similar experiments. Statistical significance of data was assessed by the Student t-test. * p < 0.01.