From: Exposure to statins and risk of common cancers: a series of nested case-control studies
 | Less than 12 months | 13 to 24 months | 25 to 48 months | 49 to 72 months | 73 months and more |  | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
cancer | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI)# | P-* value |
breast†| 363/1338 | 1 (0.86 to 1.16) | 254/962 | 0.96 (0.81 to 1.15) | 346/1208 | 1.06 (0.90 to 1.25) | 169/634 | 0.93 (0.75 to 1.15) | 131/542 | 0.85 (0.67 to 1.08) | 0.220 |
prostate | 545/2119 | 0.99 (0.87 to 1.12) | 489/1609 | 1.19 (1.04 to 1.36) | 641/2424 | 1.06 (0.94 to 1.19) | 369/1394 | 1.07 (0.93 to 1.24) | 320/1234 | 1.12 (0.96 to 1.32) | 0.173 |
colorectal‡ | 446/1527 | 1.06 (0.92 to 1.23) | 327/1224 | 1.03 (0.88 to 1.21) | 429/1625 | 0.97 (0.84 to 1.13) | 285/902 | 1.20 (1.01 to 1.43) | 213/711 | 1.21 (0.99 to 1.48) | 0.069 |
lung | 419/1375 | 1.06 (0.91 to 1.25) | 342/1064 | 1.21 (1.01 to 1.43) | 458/1586 | 1.05 (0.89 to 1.23) | 259/950 | 1.00 (0.82 to 1.21) | 235/734 | 1.17 (0.95 to 1.45) | 0.240 |
blood | 202/821 | 0.72 (0.59 to 0.88) | 160/616 | 0.8 (0.64 to 1.00) | 233/966 | 0.74 (0.61 to 0.89) | 133/468 | 0.87 (0.68 to 1.11) | 90/428 | 0.55 (0.41 to 0.73) | < 0.001 |
bladder | 172/565 | 1.14 (0.91 to 1.43) | 137/456 | 1.19 (0.93 to 1.53) | 190/681 | 1.01 (0.81 to 1.26) | 117/360 | 1.19 (0.91 to 1.57) | 94/280 | 1.37 (1.02 to 1.86) | 0.062 |
skin | 110/312 | 1.41 (1.04 to 1.89) | 56/270 | 0.79 (0.55 to 1.13) | 112/349 | 1.21 (0.89 to 1.64) | 50/176 | 0.87 (0.56 to 1.36) | 56/185 | 1.04 (0.70 to 1.55) | 0.626 |
oesophagus | 103/409 | 0.9 (0.67 to 1.20) | 75/272 | 1.01 (0.72 to 1.42) | 105/445 | 0.81 (0.61 to 1.09) | 68/248 | 1.09 (0.77 to 1.55) | 59/185 | 1.03 (0.70 to 1.52) | 0.870 |
pancreas | 76/277 | 0.89 (0.63 to 1.24) | 61/196 | 1.22 (0.84 to 1.78) | 86/286 | 0.99 (0.71 to 1.38) | 50/172 | 1.04 (0.69 to 1.56) | 40/148 | 0.85 (0.53 to 1.37) | 0.475 |
stomach | 58/232 | 0.84 (0.58 to 1.22) | 60/206 | 0.82 (0.56 to 1.19) | 77/301 | 0.86 (0.61 to 1.21) | 35/150 | 0.56 (0.35 to 0.90) | 38/165 | 0.63 (0.39 to 1.00) | 0.008 |
All cancers | 2890/10413 | 0.99 (0.94 to 1.05) | 2303/8005 | 1.05 (0.99 to 1.11) | 3107/11437 | 0.98 (0.93 to 1.03) | 1776/6319 | 1.01 (0.95 to 1.08) | 1462/5259 | 1.02 (0.95 to 1.10) | 0.958 |