Table 5 Cumulative duration of statin use in cases and controls in 13 to 120 months prior to the index date by cancer site in cases and controls with 10 or more years of recorded data
From: Exposure to statins and risk of common cancers: a series of nested case-control studies
| Â | Less than 12 months | 13 to 24 months | 25 to 48 months | 49 to 72 months | 73 months and more | Â | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
cancer | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI) # | Cases/Controls | Adjusted Odds ratio (95%CI)# | P-* value |
breast†| 363/1338 | 1 (0.86 to 1.16) | 254/962 | 0.96 (0.81 to 1.15) | 346/1208 | 1.06 (0.90 to 1.25) | 169/634 | 0.93 (0.75 to 1.15) | 131/542 | 0.85 (0.67 to 1.08) | 0.220 |
prostate | 545/2119 | 0.99 (0.87 to 1.12) | 489/1609 | 1.19 (1.04 to 1.36) | 641/2424 | 1.06 (0.94 to 1.19) | 369/1394 | 1.07 (0.93 to 1.24) | 320/1234 | 1.12 (0.96 to 1.32) | 0.173 |
colorectal‡ | 446/1527 | 1.06 (0.92 to 1.23) | 327/1224 | 1.03 (0.88 to 1.21) | 429/1625 | 0.97 (0.84 to 1.13) | 285/902 | 1.20 (1.01 to 1.43) | 213/711 | 1.21 (0.99 to 1.48) | 0.069 |
lung | 419/1375 | 1.06 (0.91 to 1.25) | 342/1064 | 1.21 (1.01 to 1.43) | 458/1586 | 1.05 (0.89 to 1.23) | 259/950 | 1.00 (0.82 to 1.21) | 235/734 | 1.17 (0.95 to 1.45) | 0.240 |
blood | 202/821 | 0.72 (0.59 to 0.88) | 160/616 | 0.8 (0.64 to 1.00) | 233/966 | 0.74 (0.61 to 0.89) | 133/468 | 0.87 (0.68 to 1.11) | 90/428 | 0.55 (0.41 to 0.73) | < 0.001 |
bladder | 172/565 | 1.14 (0.91 to 1.43) | 137/456 | 1.19 (0.93 to 1.53) | 190/681 | 1.01 (0.81 to 1.26) | 117/360 | 1.19 (0.91 to 1.57) | 94/280 | 1.37 (1.02 to 1.86) | 0.062 |
skin | 110/312 | 1.41 (1.04 to 1.89) | 56/270 | 0.79 (0.55 to 1.13) | 112/349 | 1.21 (0.89 to 1.64) | 50/176 | 0.87 (0.56 to 1.36) | 56/185 | 1.04 (0.70 to 1.55) | 0.626 |
oesophagus | 103/409 | 0.9 (0.67 to 1.20) | 75/272 | 1.01 (0.72 to 1.42) | 105/445 | 0.81 (0.61 to 1.09) | 68/248 | 1.09 (0.77 to 1.55) | 59/185 | 1.03 (0.70 to 1.52) | 0.870 |
pancreas | 76/277 | 0.89 (0.63 to 1.24) | 61/196 | 1.22 (0.84 to 1.78) | 86/286 | 0.99 (0.71 to 1.38) | 50/172 | 1.04 (0.69 to 1.56) | 40/148 | 0.85 (0.53 to 1.37) | 0.475 |
stomach | 58/232 | 0.84 (0.58 to 1.22) | 60/206 | 0.82 (0.56 to 1.19) | 77/301 | 0.86 (0.61 to 1.21) | 35/150 | 0.56 (0.35 to 0.90) | 38/165 | 0.63 (0.39 to 1.00) | 0.008 |
All cancers | 2890/10413 | 0.99 (0.94 to 1.05) | 2303/8005 | 1.05 (0.99 to 1.11) | 3107/11437 | 0.98 (0.93 to 1.03) | 1776/6319 | 1.01 (0.95 to 1.08) | 1462/5259 | 1.02 (0.95 to 1.10) | 0.958 |