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Table 4 Types of statins in cases and controls in 13 to 72 months prior to the index date (in cases and matched controls with at least 6 years of medical records)

From: Exposure to statins and risk of common cancers: a series of nested case-control studies

 

Atorvastatin

Pravastatin

Simvastatin

cancer

Cases/Controls

Adjusted Odds ratio (95%CI) #

P-value

Cases/Controls

Adjusted Odds ratio (95%CI) #

P-value

Cases/Controls

Adjusted Odds ratio (95%CI) #

P-value

breast†

596/2574

0.96 (0.86 to 1.06)

0.387

152/630

1.02 (0.85 to 1.23)

0.835

871/3720

0.98 (0.89 to 1.07)

0.584

prostate

1023/4398

0.99 (0.91 to 1.07)

0.781

314/1182

1.15 (1.00 to 1.31)

0.046

1668/6924

1.05 (0.99 to 1.13)

0.117

colorectal‡

826/2934

1.17 (1.07 to 1.28)

0.001

212/786

1.09 (0.93 to 1.28)

0.289

1152/4783

0.96 (0.88 to 1.04)

0.273

lung

786/2912

1.07 (0.97 to 1.18)

0.179

195/837

0.93 (0.78 to 1.11)

0.435

1205/4588

1.06 (0.97 to 1.15)

0.202

blood

381/1653

0.87 (0.77 to 0.99)

0.041

95/452

0.84 (0.66 to 1.06)

0.138

579/2592

0.82 (0.73 to 0.91)

< 0.001

bladder

353/1212

1.19 (1.03 to 1.37)

0.015

87/309

1.08 (0.84 to 1.40)

0.544

513/1893

1.10 (0.97 to 1.25)

0.119

skin

168/655

1.03 (0.84 to 1.25)

0.805

43/178

0.91 (0.64 to 1.30)

0.609

259/998

1.06 (0.90 to 1.26)

0.483

oesophagus

197/846

0.88 (0.73 to 1.05)

0.159

62/226

1.05 (0.78 to 1.42)

0.740

298/1222

0.94 (0.80 to 1.09)

0.403

pancreas

143/557

0.92 (0.74 to 1.14)

0.439

37/152

0.92 (0.62 to 1.35)

0.667

224/852

0.99 (0.83 to 1.20)

0.952

stomach

123/500

0.94 (0.75 to 1.18)

0.604

41/149

1.03 (0.71 to 1.50)

0.880

186/819

0.85 (0.70 to 1.03)

0.106

All cancers

5357/21253

1.01 (0.98 to 1.05)

0.461

1442/5680

1.02 (0.96 to 1.09)

0.488

8102/32769

1.00 (0.97 to 1.03)

0.844

  1. # Adjusted for Townsend quintile, body mass index, smoking status, myocardial infarction, coronary heart disease, diabetes, hypertension, stroke, rheumatoid arthritis, use of NSAIDs, Cox2-inhibitors, aspirin
  2. † Also adjusted for family history of breast cancer, benign breast disease, use of oral contraceptives, hormone-replace therapy
  3. ‡ Also adjusted for colitis and Crohn's disease
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BMC Cancer

ISSN: 1471-2407

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