Table 2 Use of statins in cases and controls in 13 to 72 months prior the index date by cancer site (in cases and matched controls with at least 6 years of medical records)
From: Exposure to statins and risk of common cancers: a series of nested case-control studies
Cancer | Total number of cases | Total number of controls | N of statin users in cases (%) | N of statin users in controls (%) | Unadjusted OR (95%CI) | Adjusted# OR (95%CI) | P-value | ||
|---|---|---|---|---|---|---|---|---|---|
breast†| 15666 | 62938 | 1481 (9.5) | 6227 (9.9) | 0.98 | (0.92 to 1.04) | 1.00 | (0.93 to 1.08) | 0.993 |
prostate | 14764 | 61853 | 2774 (18.8) | 11508 (18.6) | 1.03 | (0.98 to 1.08) | 1.08 | (1.01 to 1.14) | 0.016 |
colorectal‡ | 11749 | 48624 | 2000 (17.0) | 7770 (16.0) | 1.12 | (1.06 to 1.19) | 1.07 | (1.00 to 1.15) | 0.056 |
lung | 10163 | 42415 | 1998 (19.7) | 7621 (18.0) | 1.16 | (1.09 to 1.23) | 1.07 | (0.99 to 1.16) | 0.095 |
blood | 7185 | 29162 | 973 (13.5) | 4339 (14.9) | 0.91 | (0.84 to 0.99) | 0.78 | (0.71 to 0.86) | < 0.001 |
bladder | 4227 | 17559 | 856 (20.3) | 3125 (17.8) | 1.23 | (1.12 to 1.34) | 1.15 | (1.03 to 1.29) | 0.012 |
skin | 3249 | 13115 | 433 (13.3) | 1675 (12.8) | 1.12 | (0.99 to 1.26) | 1.08 | (0.93 to 1.26) | 0.292 |
oesophagus | 3159 | 13041 | 496 (15.7) | 2106 (16.1) | 0.97 | (0.87 to 1.09) | 0.88 | (0.77 to 1.01) | 0.072 |
pancreas | 2110 | 8762 | 365 (17.3) | 1397 (15.9) | 1.15 | (1.01 to 1.32) | 0.96 | (0.82 to 1.14) | 0.671 |
stomach | 1992 | 8279 | 322 (16.2) | 1363 (16.5) | 1.00 | (0.87 to 1.16) | 0.86 | (0.72 to 1.02) | 0.078 |
All cancers | 88125 | 362254 | 13621 (15.5) | 54606 (15.1) | 1.07 | (1.05 to 1.09) | 1.01 | (0.99 to 1.04) | 0.280 |