Table 1 Baseline characteristics for all cases with primary cancer and their matched controls with at least 6 years of medical records

   female

41749 (47.4)

170173 (47.0)

   male

46376 (52.6)

192081 (53.0)

Age band (years)

   30-54

13151 (14.9)

49906 (13.8)

   55-64

19638 (22.3)

80107 (22.1)

   65-74

26758 (30.4)

111698 (30.8)

   75-84

25013 (28.4)

106278 (29.3)

   85 +

3565 (4.0)

14265 (3.9)

Deprivation

   Townsend quintile 1, most affluent

22072 (25.0)

92287 (25.5)

   Townsend quintile 2

18998 (21.6)

79067 (21.8)

   Townsend quintile 3

17338 (19.7)

71358 (19.7)

   Townsend quintile 4

15325 (17.4)

61767 (17.1)

   Townsend quintile 5, most deprived

11896 (13.5)

45971 (12.7)

   Townsend missing

2496 (2.8)

11804 (3.3)

Body mass index (kg/m ² )

   15-24

26721 (30.3)

105883 (29.2)

   25-29

27285 (31.0)

108803 (30.0)

   30-49

12922 (14.7)

51413 (14.2)

   not recorded

21197 (24.1)

96155 (26.5)

Smoking status

   non-smoker

54307 (61.6)

233135 (64.4)

   ex-smoker

7567 (8.6)

23842 (6.6)

   current smoker

17275 (19.6)

54869 (15.1)

   not recorded

8976 (10.2)

50408 (13.9)

Co-morbidities

   Cardiovascular disease

14278 (16.2)

58123 (16.0)

   Diabetes

7115 (8.1)

26802 (7.4)

   Hypertension

27104 (30.8)

109797 (30.3)

   Osteoarthritis

12807 (14.5)

52586 (14.5)

   Rheumatoid arthritis

1310 (1.5)

5132 (1.4)

   Colitis¹

124 (1.1)

293 (0.6)

   Crohn's disease¹

28 (0.2)

109 (0.2)

   Benign breast disease²

1094 (7.0)

2937 (4.7)

   Family history of breast cancer²

539 (3.4)

1249 (2.0)

Medications (in previous 13-72 months)

   NSAID

35697 (40.5)

140642 (38.8)

   COX2 inhibitors

6901 (7.8)

26974 (7.4)

   Aspirin

19895 (22.6)

79067 (21.8)

   Hormone replace therapy²

3289 (21.0)

10973 (17.4)

   Oral contraceptive pill²

523 (3.3)

1638 (2.6)