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Table 3 Multivariate analysis of clinical and biochemical factors

From: Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid

Clinical and biochemical factor category HR (95% CI) P
Previous chemotherapy regimen ≤ 2 1 0.000
  > 2 7.803 (2.884-21.112)  
ER status - 1 0.001
  + 0.295 (0.141-0.618)  
Baseline NTx ≤ 18 nM BCE 1 0.001
  > 18 nM BCE 2.842 (1.458-5.539)  
VEGF (days 90) ≤ 500 pg/ml 1 0.020
  > 500 pg/ml 2.220 (1.136-4.338)