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Figure 1 | BMC Cancer

Figure 1

From: Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid

Figure 1

Kaplan-Meier curves for progression-free survival with different biochemical and clinical factors. A. Kaplan-Meier curves for progression-free survival. Notes: Patients with numbers of positive lymph nodes no more than 3 (N = 47), median = 6.3 months (95% CI, 4.1-8.6 months); patients with numbers of positive lymph nodes more than 3 (N = 13), median = 2.7 months (95% CI, 1.2-4.2 months); P = 0.012. B. Kaplan-Meier curves for progression-free survival. Notes: Patients with DFI no less than 2 years (N = 43), median = 6.4 months (95% CI, 2.9-10.0 months); patients with DFI less than 2 years (N = 13), median = 5.1 months (95% CI, 3.6-6.7 months); P = 0.018. C. Kaplan-Meier curves for progression-free survival. Notes: Patients with ER positive (N = 40), median = 7.0 months (95% CI, 5.3-8.8 months); patients with ER negative (N = 18), median = 2.8 months (95% CI, 2.2-3.4 months); P = 0.010. D. Kaplan-Meier curves for progression-free survival. Notes: Patients treated with 2 or less than 2 regimens (N = 48), median = 6.4 months (95%CI, 4.5-8.3 months); patients treated with more than 2 regimens (N = 12), median = 1.6 months (95%CI, 0.1-3.1 months); P = 0.024. E. Kaplan-Meier curves for progression-free survival. Notes: Patients with serum CEA baseline levels of less than 10 μg/L (N = 42), median = 6.4 months (95% CI, 4.6-8.3 months); patients with serum CEA baseline levels of greater than 10 μg/L (N = 18), median = 3.0 months (95% CI, 0-6.8 months); P = 0.019. F. Kaplan-Meier curves for progression-free survival. Notes: Patients with serum CA 15-3 baseline levels of less than 25 U/mL (N = 21), median = 10.6 months (95% CI, 3.5-17.8 months); patients with serum CA 15-3 baseline levels of greater than 25 U/mL (N = 38), median = 4.2 months (95% CI, 1.0-7.3 months); P = 0.008. G. Kaplan-Meier curves for progression-free survival. Notes: Patients with serum VEGF levels after 3 months of intervention of less than 500 pg/mL (N = 29), median = 10.0 months (95% CI, 4.3-15.7 months); patients with serum VEGF levels of 500 pg/mL or greater after 3 months of intervention (N = 21), median = 4.0 months (95% CI, 2.0-6.1 months); P = 0.014. H. Kaplan-Meier curves for progression-free survival. Notes: Patients with serum NTx baseline levels less than 18 nM BCE (N = 28), median = 8.1 months (95% CI, 4.2-11.9 months), patients with serum NTx baseline levels greater than 18 nM BCE (N = 32), median = 4.2 months (95% CI, 1.0-7.2 months); P = 0.003.

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