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Figure 7 | BMC Cancer

Figure 7

From: Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics

Figure 7

Repression of Snail1 attenuates Nanog promoter activity and tumor proliferation. (A) Relative gene expression of Snail1, Nanog, and CD44 of mesenchymal-scrambled-shRNA compared to mesenchymal-Snail1-shRNA cells. Bars represent mean ± SEM of triplicates, *p < 0.05. Western blot of Snail1 and β-actin, with blots representative of two independent experiments. (B) Inhibition of Snail1 reduces Nanog luciferase activity. Data presented are shown as mean ± SEM of three independent experiments, *p < 0.05. (C) Tumors of indicated number of cells of mesenchymal-scrambled-shRNA or mesenchymal-Snail1-shRNA knock-down cells. Tumor volume reported as mean ± SEM, *p < 0.05; N = 4/group. Relative Snail1 mRNA expression of tumor tissues. Data presented are reported as mean ± SEM of all Scrambled and Snail1 tumor tissues, *p < 0.05; N = 4/group.

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