Figure 4

Correlation of expression of miR-183 family with clinical-pathological features of lung cancer. The Mann-Whitney U-test was used to examine the correlation between miR-183 family levels and clinical-pathological features. The results showed that (A) Tumor miR-96, miR-182, and miR-183, and serum miR-96 expression were higher in squamous-cell lung carcinoma than in adenocarcinoma (P = 0.0216, 0.0190, 0.0042, and 0.0310, respectively). (B) Tumor miR-183 expression was higher in NSCLC patients with lymph node metastasis than without lymph node metastasis (P = 0.0086). (C) Tumor miR-182 and miR-183 expressions were higher in NSCLC patients with tumor invasion to lung membrane than without invasion to lung membrane (P = 0.0222 and 0.0140, respectively). (D) Tumor and serum miR-182 levels were higher in NSCLC patients with tumor size > 3 cm than those with tumor size < 3 cm (P = 0.0464 and 0.0351, respectively). (E) Tumor miR-183 expression was higher in stages II, III, and IV NSCLC samples than in stage I. Differences were significant after the Mann Whitney U-test. *Indicates a significant difference between groups (P < 0.05).