Figure 3

Sensitivity of SW948 and SW948-TR cells to agonistic DR4 and DR5 antibodies. A: Survival (%) of SW948 and SW948-TR after continuous incubation with agonistic DR4 antibody and agonistic DR5 antibody as measured by cytotoxicity assays. B: Apoptosis assay in SW948 and SW948-TR. Cells were pre-incubated with 5 μg/ml CHX for 1 h before incubation with various concentrations of agonistic DR4 antibody (DR4 Ab) and agonistic DR5 antibody (DR5 Ab) for 24 h.