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Table 1 Study population characteristics

From: Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study

 

Cases

(n = 68)

Controls

(n = 68)

P-value††

Age at enrollment (years)

   

   Mean (SD)

60.2 (5.6)

60.3 (5.7)

0.966

BMI

   

   Mean (SD)

26.6 (3.1)

26.3 (3.6)

0.603

   Missing

1

-

 

Use of oral contraceptives, n (%)

   

   No, but used to in the past

36 (52.9)

40 (58.8)

0.490

   No, never

32 (47.1)

28 (41.2)

 

Duration of oral contraceptives use* (years)

   

   Median (IQR)

10.0 (4.3-15.8)

4.5 (2.0-10.0)

0.018

Use of HT, n (%)

   

   No, but used to in the past

7 (10.3)

6 (8.8)

0.771

   No, never

61 (89.7)

62 (91.2)

 

Duration of HT use* (years)

   

   Median (IQR)

1.0 (1.0-8.0)

2.0 (1.0-10.0)

0.273

Ovariectomy, n (%)

   

   Both ovaries removed

5 (7.4)

3 (4.5)

0.479

   Missing

-

1

 

Parity, n (%)

   

   Nulliparous

10 (14.7)

5 (7.4)

0.171

Number of children

   

   Median (IQR)

2.0 (2.0-3.0)

3.0 (2.0-3.0)

0.100

Smoking, n (%)

   

   No, but used to in the past

31 (45.6)

34 (50.0)

0.607

   No, never

37 (54.4)

34 (50.0)

 

Pack-years smoking until stop date

   

   Median (IQR)

7.9 (1.9-16.4)

4.1 (1.4-10.2)

0.187

   Missing

1

3

 

Alcohol intake (g/day)§

   

   Median (IQR)

2.0 (0.2-7.2)

2.5 (0.2-8.4)

0.638

Use of medicines, minerals or vitamins #, n (%)

   

   Yes

46 (67.6)

44 (64.7)

 

   No

22 (32.4)

24 (35.3)

0.717

Time since last meal and/or drink** (min)

   

   Median (IQR)

108 (87-137)

116 (88-137)

0.651

  1. SD: standard deviation; BMI: body mass index; IQR: inter-quartile range; HT: menopausal hormone therapy; * Among former oral contraceptives/HT users; Among women with children; Among former smokers; § Energy-adjusted alcohol intake at enrollment; # In last week before blood collection; ** At moment of blood collection; †† Independent samples T test for age and BMI, Mann-Whitney U test for other continuous variables, and Pearson Chi-Square test for categorical variables.