FLT3 ITD mutations in exon 14. The amino acid sequences of the three FLT3 ITD mutations are shown, with the duplicated region shown below the wild-type sequence of exon 14 for each case. The bolded amino acid(s) are not part of the wild-type sequence and exist between the two repeats (not duplicated). The underlined residue in Case 2 is mutated in the duplication only; the other copy is wild-type. Each of the three ITD mutations are in-frame.