Antioxidants and breast cancer risk- a population-based case-control study in Canada

Pan, Sai Yi; Zhou, Jia; Gibbons, Laurie; Morrison, Howard; Wen, Shi Wu

doi:10.1186/1471-2407-11-372

BMC Cancer

Table 4 ORs of breast cancer associated with supplementation of antioxidants, NECSS,Canada,1994-1997

From: Antioxidants and breast cancer risk- a population-based case-control study in Canada

	Premenopausal				Postmenopausal
Variable	Cases	Controls	OR † (95% CI)	p trend	Cases	Controls	OR†† (95% CI)	p trend
Multiple vitamin (years)				0.53				0.04
0 (never taken)*	269	249	1.00		654	731	1.00
≤ 2 year	282	294	0.86 (0.67-1.10)		312	335	0.91 (0.75-1.11)
3-9 year	180	177	0.85 (0.64-1.13)		292	268	1.03 (0.83-1.27)
≥ 10 years	135	125	0.93 (0.69-1.27)		238	283	0.74 (0.59-0.92)
Vitamin A (years)				0.26				0.31
0 (never taken)*	690	677	1.00		1235	1350	1.00
≤ 2 year	105	95	1.02 (0.75-1.39)		127	133	0.90 (0.69-1.19)
3-9 year	47	40	1.03 (0.65-1.61)		72	61	1.12 (0.77-1.63)
≥ 10 years	24	33	0.61 (0.35-1.06)		62	73	0.77 (0.53-1.11)
Beta-carotene (years) #				0.86				0.15
0 (never taken)*	675	689	1.00		1219	1348	1.00
≤ 2 year	144	93	1.54 (1.16-2.06)		182	162	1.01 (0.79-1.29)
3-9 year	35	42	0.85 (0.53-1.37)		63	60	1.01 (0.69-1.49)
≥ 10 years	12	21	0.51 (0.24-1.06)		32	47	0.58 (0.36-0.95)
Vitamin C (years) #				0.26				0.07
0 (never taken)*	337	357	1.00		687	792	1.00
≤ 2 year	267	223	1.20 (0.94-1.53)		306	317	0.86 (0.70-1.05)
3-9 year	165	148	1.08 (0.82-1.43)		268	261	0.96 (0.77-1.19)
≥ 10 years	97	117	0.75 (0.54-1.03)		235	247	0.79 (0.63-0.99)
Vitamin E (years) #				0.25				0.05
0 (never taken)*	493	513	1.00		822	935	1.00
≤ 2 year	245	171	1.46 (1.15-1.85)		316	286	1.05 (0.86-1.28)
3-9 year	89	113	0.73 (0.53-1.01)		209	220	0.91 (0.72-1.15)
≥ 10 years	39	48	0.74 (0.47-1.17)		149	176	0.75 (0.58-0.97)
Zinc (years) #				0.004				0.02
0 (never taken)*	736	688	1.00		1297	1420	1.00
≤ 2 year	85	95	0.81 (0.58-1.11)		120	94	1.14 (0.84-1.53)
3-9 year	27	33	0.73 (0.43-1.25)		52	56	0.83 (0.55-1.26)
≥ 10 years	18	29	0.46 (0.25-0.85)		27	47	0.47 (0.28-0.78)
Selenium (years) #				0.59				0.85
0 (never taken)*	755	754	1.00		1355	1504	1.00
≤ 2 year	85	50	1.65 (1.13-2.40)		88	56	1.43 (0.98-2.05)
3-9 year	16	27	0.59 (0.31-1.12)		29	30	0.90 (0.52-1.57)
≥ 10 years	10	14	0.57 (0.25-1.34)		24	27	0.75 (0.42-1.34)

* Reference category
† Adjusted for age, province of residence, education, smoking pack years, alcohol consumption, number of live births, age at menarche, and total energy intake.
†† Adjusted for age, province of residence, education, smoking pack years, alcohol consumption, BMI, recreational physical activity, number of live births, age at menarche, and total energy intake.
# also adjusted for antioxidant intake from diet.

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ISSN: 1471-2407

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