BA inhibits colon tumor growth in vivo. Inhibition of tumor growth (A) and weights (B). BA (25 mg/kg/d) was administered (orally) to athymic nude mice every second day and tumor volumes and weights were determined as described in the Materials and Methods. (C) Downregulation of Sp1, Sp3 and Sp4. Tumor lysates from individual mice were analyzed by western blots as described in the Materials and Methods and Sp1, Sp3 and Sp4 protein levels were normalized to β-actin. Results in (A) - (C) are means ± SE for at least 8 mice in the control (corn oil) and BA-treated groups and significant (p < 0.05) inhibition by BA is indicated (*).