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Table 4 The selected published series on acute toxicity rate for postoperative external beam radiation therapy/intensity-modulated radiation therapy/helical tomotherapy for locally advanced head and neck cancer and/or oral cavity cancer patients

From: Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Institute Treatment (percentage of using chemotherapy) Fistula formation/or skin dehiscence *≥ Grade 3
    dermatitis mucosistis Body weight loss ^Xerostomia (acute) Anemia Leukopenia Thrombocytopenia
RTOG 9501[4] OP+RT+C/T - 8% 30% - 2%   38% (all of hematologic effects)  
EORTC 22931[5] OP+RT+C/T - - 41% - 14% - 16% -
RTOG 0024[14] OP+RT+C/T 11% 29% 60% - -   12% (all of hematologic effects)  
Yu et al.[23] OP+RT 8-29% - - - - - - -
Jeremic et al.[24] RT+C/T - - - 29% - - - -
Capuano et al.[25] RT+C/T - - - 17% - - - -
Gomez et al.[19] OP+IMRT +C/T (29%) - 3% 23% - 0% - - -
Chen WC et al. Taiwan [17] OP+IMRT +C/T (9%) - 0 14% - - - - -
FEMH, Taiwan OP+HT +C/T (84%) 11% 5% 42% `0% `0% 0% 5% 0%
  1. ^Toxicity of xelostomia (Acute): Acute toxicities is defined as occurring < 90 days after beginning RT.
  2. *The grade of toxicity is according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0).
  3. Abbreviations:
  4. OP = operation; RT = External beam radiation therapy; IMRT = intensity-modulated radiation therapy; HT = helical tomotherapy; C/T chemotherapy; FEMH = Far Eastern Memorial Hospital.